538916

16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem

A cell-permeable and orally available synthetic PGE2.

• Sinónimos: 16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem
• Fórmula empírica (notación de Hill): C₂₂H₃₆O₅
• Número de CAS: 39746-25-3
• Peso molecular: 380.52
• Número MDL: MFCD00151141
• Código UNSPSC: 12352200

Propiedades

• Análisis: ≥95% (HPLC)
• formulario: liquid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• solubilidad: DMSO: 100 mg/mL; ethanol: 100 mg/mL; PBS, pH 7.2: 5 mg/mL
• Condiciones de envío: wet ice
• temp. de almacenamiento: −70°C
• InChI: 1S/C22H36O5/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h6,8,12-13,16-17,19-20,24-25H,4-5,7,9-11,14-15H2,1-3H3,(H,26,27)/b8-6+,13-12+/t16-,17?,19-,20+/m0/s1
• Clave InChI: QAOBBBBDJSWHMU-BKSAQPBESA-N

Descripción

Descripción general

A cell-permeable and orally available synthetic PGE2.

A cell-permeable and orally available synthetic PGE₂ (Cat. No. 538904) 16,16-dimethyl derivative that exhibits similar biological activity as PGE₂ as an EP receptor agonist both in in vitro and in in vivo, while being more resistant to PGDH metabolism. Shown to amplify wnt activity through cAMP/PKA-mediated regulation of cellular β-catenin protein stability during vertebrate development and organ regeneration.

A cell-permeable and orally available synthetic PGE₂ (Cat. No. 538904) 16,16-dimethyl derivative that exhibits similar biological activity as PGE₂ as an EP receptor agonist both in in vitro and in in vivo, while being more resistant to PGDH metabolism. Shown to amplify wnt activity through cAMP/PKA-mediated regulation of cellular β-catenin protein stability during vertebrate development and organ regeneration.

Advertencia

Toxicity: Flammable (J)

Forma física

Supplied as a solution in methylacetate (1 mg/100 µL)

Nota de preparación

Gently blow away methylacetate under a stream of N2 and solubilize in either DMSO or EtOH purged with an inert gas.

Reconstitución

Following reconstitution in DMSO or EtOH store at ≤-70°C for up to 6 months; Store aqueous solutions on ice and use within 12 hrs.

Otras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Goessling, W., et al. 2009. Cell136, 1136.
Fitzgerald, J., et al. 2000. Endocrinology141, 291.
Coleman, R.A., et al. 1994. Pharmacol. Rev.46, 205.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS02,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H225,H319,H336
• Consejos de prudencia: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• Órganos de actuación: Central nervous system
• Riesgos supl.: EUH066
• Código de clase de almacenamiento: 3 - Flammable liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): 3.2 °F - closed cup
• Punto de inflamabilidad (°C): -16 °C - closed cup