529605-M

PP1 Analog

InSolution, ≥97%, ATP-competitive, inhibitor of Src-family tyrosine kinases

• Sinónimos: InSolution PP1 Analog
• Fórmula empírica (notación de Hill): C₁₉H₁₉N₅
• Número de CAS: 221243-82-9
• Peso molecular: 317.39
• Código UNSPSC: 12352200

Propiedades

• Análisis: ≥97% (HPLC)
• formulario: liquid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• temp. de almacenamiento: −70°C
• InChI: 1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22)
• Clave InChI: XSHQBIXMLULFEV-UHFFFAOYSA-N

Descripción

Descripción general

A potent, reversible, ATP-competitive, and cell-permeable inhibitor of Src-family tyrosine kinases that is >800 times more selective for the I338G mutant v-Src (IC₅₀ = 1.5 nM) compared to wild-type v-Src (IC₅₀ = 1.0 µM). Also inhibits wild-type Fyn (IC₅₀ = 600 nM). A 10 mM (1 mg/315 µl) solution of PP1 Analog (Cat. No. 529579) in DMSO.

A potent, reversible, ATP-competitive, and cell-permeable inhibitor of Src-family tyrosine kinases that is >800 times more selective for the I338G mutant v-Src (IC₅₀ = 1.5 nM) compared to wild-type v-Src (IC₅₀ = 1.0 µM). Also inhibits wild-type Fyn (IC₅₀ = 600 nM). A 10 mM (1 mg/315 µl) solution of PP1 Analog (Cat. No. 529579) in DMSO.

Advertencia

Toxicity: Irritant (B)

Forma física

A 10 mM (1 mg/315 µl) solution of PP1 Analog (Cat. No. 529579) in DMSO.

Reconstitución

Following initial thaw, aliquot and freeze (-70°C).

Otras notas

Bishop, A.C., et al. 2000. Nature407, 395.
Bishop, A.C., et al. 1999 J. Am. Chem. Soc.121, 627.

Información legal

Not available for sale in the United States.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Punto de inflamabilidad (°C): 87 °C - closed cup - (Dimethylsulfoxide)