5.09884

Myristoylated-FEEERA, mP6

• Sinónimos: Myristoylated-FEEERA, mP6, Integrin Signaling Inhibitor I, mP6
• Fórmula empírica (notación de Hill): C₄₇H₇₅N₉O₁₄
• Peso molecular: 990.15
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Análisis: ≥98% (HPLC)
• Nivel de calidad: 100
• formulario: powder
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubilidad: DMSO: 100 mg/mL
• temp. de almacenamiento: −70°C

Descripción

Descripción general

A cell-permeable myristoylated hexapeptide derived from EXE-motif-containing integrin β3 subunit that selectively inhibits integrin outside-in signaling without affecting inside-out signaling . Shown to specifically block the interaction of Gα3 and integrin β3 subunit resulting in the inhibition of Gα13-dependent early phase outside-in signaling. Selectively inhibits thrombosis without affecting haemostasis.

A cell-permeable myristoylated hexapeptide derived from EXE-motif-containing integrin β3 subunit that selectively inhibits integrin outside-in signaling without affecting inside-out signaling . Shown to specifically block the interaction of Gα3 and integrin β3 subunit resulting in the inhibition of Gα13-dependent early phase outside-in signaling. Selectively inhibits thrombosis without affecting haemostasis.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
platelet integrin →IIb→3

Reversible: yes

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Secuencia

FEEERA

Reconstitución

Following reconstitution, aliquot and freeze (-207deg;C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Shen, B., et al. 2013. Nature503, 131.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable