5.04359

Palmitoylethanolamide

• Sinónimos: Palmitoylethanolamide, N-(2-Hydroxyethyl)hexadecanamide, PEA, Palmidrol
• Fórmula empírica (notación de Hill): C₁₈H₃₇NO₂
• Número CAS: 544-31-0
• Peso molecular: 299.49
• UNSPSC Code: 51111800
• NACRES: NA.77
• MDL number: MFCD00020562
• Assay: ≥99% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Propiedades

• assay: ≥99% (HPLC)
• Quality Segment: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white
• solubility: DMSO: 20 mM
• storage temp.: −20°C
• SMILES string: N(CCO)C(=O)CCCCCCCCCCCCCCC
• InChI: 1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h20H,2-17H2,1H3,(H,19,21)
• InChI key: HXYVTAGFYLMHSO-UHFFFAOYSA-N

Descripción

General description

An endogenous lipid that acts as a selective agonist for GPR55 receptors (EC₅₀ = 4, 19 800 and >30 000 nM at GPR55, CB₂ and CB₁ receptors respectively). Producing robust anti-inflammatory actions by activating PPARα (EC₅₀ = 3 µM).

Biochem/physiol Actions

Primary Target
GPR55 receptor

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Slight warming is required for complete solubilization.

Other Notes

Griffin, G., et al. 2000. J. Pharmacol. Exp. Ther.292, 886.

Lambert, D., et al. 2001. Epilepsia.42, 321.
Lambert, D., et al. 2002. Curr. Med. Chem.9, 663.
Lo Verme, J., et al. 2005. Life Sci.77, 1685.
Re, G., et al. 2005. Vet. J.173, 21.
Ryberg, R., et al. 2007. Br. J. Pharmacol.152, 1092.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Información de seguridad

• pictograms: GHS05,GHS09
• signalword: Danger
• pcodes: P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Hazard Classifications: Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2
• Clase de almacenamiento: 13 - Non Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• hcodes: H315,H318,H411