475895

Monensin, Sodium Salt, High Purity

Polyether antibiotic that functions as a Na⁺ ionophore by forming stable complexes with monovalent cations that are able to cross the plasma membrane.

• Sinónimos: Monensin, Sodium Salt, High Purity
• Fórmula empírica (notación de Hill): C₃₆H₆₁O₁₁ · Na
• Número de CAS: 22373-78-0
• Peso molecular: 692.85
• Número MDL: MFCD00077826
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Análisis: ≥97% (by Assay)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• color: off-white to beige
• solubilidad: chloroform: soluble; ethanol: soluble; methanol: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40;/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40);/q;+1/p-1/t19-,20-,21+,22+,23-,24-,25-,26+,27+,28-,29+,30-,31+,33-,34-,35+,36-;/m0./s1
• Clave InChI: XOIQMTLWECTKJL-FBZUZRIGSA-M

Descripción

Descripción general

Polyether antibiotic that functions as a Na⁺ ionophore by forming stable complexes with monovalent cations that are able to cross the plasma membrane. Blocks glycoprotein secretion. Inhibits the ability of HDL to decrease cellular cholesterol esterification. Also reported to induce catecholamine secretion from adrenal chromaffin cells.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
Functions as a Na+ ionophore

Product does not compete with ATP.

Reversible: no

Advertencia

Toxicity: Highly Toxic (H)

Reconstitución

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C. Unstable in acidic solutions.

Otras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Inabayashi, M., et al. 1995. Biochemistry34, 3455.
Mendez, A.J. 1995. J. Biol. Chem.270, 5891.
Sakuragawa, N., et al. 1994. Biochim. Biophys. Acta1213, 193.
Griffin, T., et al. 1993. J. Natl. Cancer Inst.85, 292.
Rushfeldt, C., and Smedsrtod, B. 1993. Cancer Res.53, 658.
Hoya, A., and Venosa, R.A. 1992. Biochem. Biophys. Acta1104, 123.
Kok, J.W. 1992. J. Cell. Sci.103, 1139.
Takemura, H., and Ohshika, H. 1992. Biochem. Pharmacol.44, 1395.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS06,GHS08,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H300,H319,H373,H411
• Consejos de prudencia: P260 - P264 - P273 - P301 + P310 - P305 + P351 + P338 - P314
• Clasificaciones de peligro: Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - STOT RE 2
• Órganos de actuación: Heart,muscle
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable