440205-M

LY 83583

A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC₅₀ = 2 µM).

• Sinónimos: LY 83583, 6-Anilino-5,8-quinolinequinone
• Fórmula empírica (notación de Hill): C₁₅H₁₀N₂O₂
• Número de CAS: 91300-60-6
• Peso molecular: 250.25
• Número MDL: MFCD00210756
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Análisis: ≥98% (HPLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• color: red-purple
• solubilidad: ethanol: 3 mg/mL; acetone: soluble
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C15H10N2O2/c18-13-9-12(17-10-5-2-1-3-6-10)15(19)11-7-4-8-16-14(11)13/h1-9,17H
• Clave InChI: GXIJYWUWLNHKNW-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC₅₀ = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca²⁺ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells.

A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC₅₀ = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca²⁺ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells. Also inhibits neutrophil chemotaxis induced by NO donors.

Acciones bioquímicas o fisiológicas

Primary Target
soluble guanylate cyclase

Target IC₅₀: 2 µM against soluble guanylate cyclase

Advertencia

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstitución

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C or up to 6 months at -20°C.

Otras notas

Adachi, R., et al. 2000. Int. J. Immunopharmacol. 22, 855.
Kawada, T., et al. 1994. Gen. Pharmacol. 25, 1361.
Beasley, D., et al. 1991. J. Clin. Invest. 87, 602.
Pandol, S.J., et al. 1990. J. Biol. Chem.265, 12846.
Light, D.B., et al. 1989. Science 243, 383.
Mulsch, A. 1988. J. Pharmacol. Exp. Ther.247, 283.
Fleisch, J.H., et al. 1984. J. Pharmacol. Exp. Ther. 229, 681.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable