407673

Interleukin-8, Human, Recombinant, E. coli

• Sinónimos: rhIL-8
• Código UNSPSC: 12352202

Propiedades

• Análisis: ≥97% (SDS-PAGE)
• Nivel de calidad: 100
• formulario: lyophilized
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• impurezas: ≤100 EU/μg Endotoxin (EU/μg IL-8)
• Condiciones de envío: ambient
• temp. de almacenamiento: −70°C

Descripción

Descripción general

Recombinant, human interleukin-8 expressed in E. coli. A potent proinflammatory cytokine produced by monocytes, fibroblasts, and keratinocytes in response to stimulation by LPS, IL-1, or TNF-α, and by T lymphocytes in response to PHA stimulation. Induces adhesion of neutrophils to endothelial cells. A physiological initiator of chemotactic migration of leukocytes. May be involved in chronic inflammation. IL-8 acts as an angiogenic factor in human gastric carcinoma.

Recombinant, human interleukin-8 expressed in E. coli. IL-8 is produced by monocytes, fibroblasts, and keratinocytes in response to stimulation by LPS, IL-1, or TNFα, and by T lymphocytes in response to PHA stimulation. Induces adhesion of neutrophils to endothelial cells. May be involved in chronic inflammation.

Acciones bioquímicas o fisiológicas

ED₅₀ = 150-300 ng/ml as measured by induction of myeloperoxidase release from human neutrophils

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 month at 4°C or up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.

Reconstitute to a concentration ≥10 µg/ml with sterile PBS containing at least 0.1% HSA or BSA.

Otras notas

Kido, S., et al. 2001. Eur. J. Cancer37, 1482.
Wilson, A.J., et al. 1999. Clin. Sci. 97, 385.
Harada, A., et al. 1994. J. Leukoc. Biol.56, 559.
Mazzucchelli, L., et al. 1994. Am. J. Pathol. 144, 997.
Oppenheim, J.J., et al. 1991. Annu. Rev. Immunol.9, 617.
Matsushima, K., et al. 1988. J. Exp. Med.167, 1883.
Schröeder, J., et al. 1987. J. Immunol.139, 3474.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable