3779

Histamine, Free Base

• Sinónimos: Histamine, Free Base
• Fórmula empírica (notación de Hill): C₅H₉N₃
• Número de CAS: 51-45-6
• Peso molecular: 111.15
• Número MDL: MFCD00005210
• Código UNSPSC: 12352209
• NACRES: NA.77

Propiedades

• Análisis: ≥97% (TLC)
• Nivel de calidad: 100
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubilidad: water: 1 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
• Clave InChI: NTYJJOPFIAHURM-UHFFFAOYSA-N

Descripción

Descripción general

A potent vasodilator found in normal tissues and blood. Activates nitric oxide synthase.

A potent vasodilator found in normal tissues and blood. Activates nitric oxide synthase. Formed by the decarboxylation of L-histidine. Activation of histamine H₁ receptors leads to Ca²⁺ mobilization, whereas histamine H₂ receptor activation stimulates adenylate cyclase activity in neurons. Stimulated time- and concentration-dependent increase in p38 and p42/p44 MAP kinases in DDT(1) MF2 cells.

A potent vasodilator found in normal tissues and blood. Formed by the decarboxylation of L-histidine. Activates nitric oxide synthase (NOS), resulting in the release of nitric oxide. Activation of histamine H₁ receptors leads to Ca²⁺ mobilization; whereas, histamine H₂ receptor activation stimulates adenylate cyclase activity in neurons. Inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H₂ receptor activation.

Envase

Packaged under inert gas

Advertencia

Toxicity: Harmful (C)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Robinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol.133, 178.
Izumi, H., et al. 1995. Am. J. Obstet. Gynecol.172, 1477.
Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem.269, 9952.
Yan, Q.Z., et al. 1994. Agents Actions 41, C111.
Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H301,H315,H317,H319,H334,H335
• Consejos de prudencia: P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable