370700

GW9662 - CAS 22978-25-2 - Calbiochem

• Sinónimos: 2-Chloro-5-nitro-N-phenylbenzamide

Propiedades

• assay: ≥95% (HPLC)
• form: crystalline solid
• solubility: DMSO: 20 mg/mL, methanol: soluble

Descripción

General description

A cell-permeable, selective and irreversible PPARγ antagonist (IC₅₀ = 3.3 nM, 32 nM, and 2 μM for PPARγ, PPARα, and PPARδ, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 μM, also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor-α (LXR_α), retinoic acid receptor (RAR), retinoid X receptor-α (RXR_α) and thyroid receptors α and β (TR_α and TR_β).

Biochem/physiol Actions

Target IC₅₀:3.3 nM, 32 nM, and 2 μM for PPARγ, PPARα, and PPARΔ

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Información de seguridad

• Clase de almacenamiento: 10-13 - German Storage Class 10 to 13