344580

FtsZ Polymer Stabilizer, PC190723

• Sinónimos: FtsZ Polymer Stabilizer, PC190723, 3-((6-chlorothiazolo[5,4-b]pyridin-2-yl)methoxy)-2,6-difluorobenzamide, FtsZ Polymer-stabilizing Agent, Filamenting Temperature-Sensitive Mutant Z Polymer Stabilizer
• Fórmula empírica (notación de Hill): C₁₄H₈ClF₂N₃O₂S
• Peso molecular: 355.75
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Análisis: ≥97% (HPLC)
• Nivel de calidad: 100
• formulario: powder
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: tan
• solubilidad: DMSO: 10 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C

Descripción

Descripción general

A benzamide ether derivative that exhibits potent bactericidal activity against Staphylococcus aureus and Bacillus subtilis (minimum inhibitory concentration = 0.5 to 1 μg/ml), but does not affect E. coli, yeast, or human hepatocytes. Shown to reduce GTPase activity and induce FtsZ (a prokaryotic homologue of tubulin) polymerization in S. aureus in a dose-dependent manner. Reported to directly inhibit the GTPase activity of FtsZ in a concentration dependent manner (IC₅₀ = 55 ng/ml). Shown to bind between the C-ternimal domain and helix 7 in a region analogous to the Taxol binding site of tubulin. Increases the survival rate to 100% in mice subjected to a lethal dose of S. aureus.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
FtsZ

Reversible: yes

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Elsen, N. L., et al. 2012. J. Am. Chem. Soc.134, 12342.
Andreu, J. M., et al. 2010. J. Biol. Chem.285, 14239.
Haydon, D. J., et al. 2008. Science, 321, 1673.
Sorto, N. A., et al. 2010. J. Org. Chem.75, 7946.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable