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23-055-M

Cardiac Troponin I, 10 µg

Full length, recombinant human Cardiac Troponin I. N-terminal c-Myc, GST-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays.

Sinónimos:

Troponin I, cardiac muscle, TNNI3, TNNC1

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A ustedes/SKUDisponibilidadPrecio
10 μg
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
657,00 €
250 μg
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3670,00 €

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UNSPSC Code:
12352202
NACRES:
NA.41
eCl@ss:
32160405
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf21 cells

657,00 €


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biological source

human

Quality Segment

recombinant

expressed in baculovirus infected Sf21 cells

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable

NCBI accession no.

General description

Troponin is a complex of three regulatory proteins (Troponin I, Troponin T and Troponin C). It is located on the actin filament and is essential for the calcium-mediated regulation of skeletal and cardiac muscle contraction. There are tissue-specific isoforms of Troponin I, T and C and two subtypes (Cardiac Troponin I and T) are released when the heart muscle has been damaged, such as during a heart attack. The more damage there is to the heart, the greater the amount of Troponin I and T there will be in the blood and currently, Cardiac Troponin I and T are used as the preferred biochemical markers for the diagnosis of myocardial infarction. It has also been demonstrated that Cardiac Troponin I is targeted for degradation by MuRF1, an E3 ubiquitin ligase that has been linked to muscle atrophy

Application

Ubiquitination Cascade Comoponent: Substrate

Physical form

Purified using immobilized metal affinity chromatography.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Este artículo
MABT546SRP5147MABT368
technique(s)

activity assay: suitable

technique(s)

western blot: suitable

technique(s)

-

technique(s)

immunohistochemistry: suitable, western blot: suitable

recombinant

expressed in baculovirus infected Sf21 cells

recombinant

-

recombinant

expressed in E. coli

recombinant

-

biological source

human

biological source

mouse

biological source

human

biological source

mouse

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

100

NCBI accession no.

NM_000363

NCBI accession no.

NP_000354

NCBI accession no.

NM_003281

NCBI accession no.

NP_000355

manufacturer/tradename

Upstate®

manufacturer/tradename

-

manufacturer/tradename

-

manufacturer/tradename

-


pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Sens. 1

Clase de almacenamiento

12 - Non Combustible Liquids

flash_point_f

Not applicable

flash_point_c

Not applicable



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