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220551

Sigma-Aldrich

Chloramphenicol

Chloramphenicol, CAS 56-75-7, is a synthetic bacteriostatic antibiotic that inhibits the translation of RNA by blocking the peptidyltransferase reaction on ribosomes.

Sinónimos:

Chloramphenicol

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About This Item

Fórmula empírica (notación de Hill):
C11H12Cl2N2O5
Número de CAS:
56-75-7
Peso molecular:
323.13
Número MDL:
MFCD00078159
Código UNSPSC:
12352200

Nivel de calidad

100

Análisis

≥97% (by Assay)

formulario

crystalline powder

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

OK to freeze

color

gray to off-white

solubilidad

water: 2.5 mg/mL
methanol: 35 mg/mL
ethanol: soluble

Condiciones de envío

ambient

temp. de almacenamiento

10-30°C

InChI

1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)

Clave InChI

WIIZWVCIJKGZOK-UHFFFAOYSA-N

Descripción general

Synthetic bacteriostatic antibiotic that inhibits the translation of RNA by blocking the peptidyltransferase reaction on ribosomes.
Synthetic bacteriostatic antibiotic that inhibits the translation of RNA to protein by binding to the 50S ribosomal subunit, blocking the peptidyl transferase reaction. Chloramphenicol resistance is encoded by the resistance gene cat, whose product, chloramphenicol acetyltransferase, inactivates the antibiotic via acetylation. Typically used at 30-50 µg/ml for selection of chloramphenicol-resistant Escherichia coli.

Acciones bioquímicas o fisiológicas

Potency: ≥970 µg/mg
Primary Target
trasnslation of RNA

Otras notas

Lech, K., and Brent, R. 1995. in Current Protocols in Mol. Biol. Vol. 1, (Ausubel, F.M., et al., Eds.) John Wiley & Sons, New York.
Lu, J., and Jiang, C. 1993. Biochem. Biophys. Res. Commun.196, 12.
Saltarelli, M.J., et al. 1993. Virol.197, 35.
Holt, J.T. 1992. Ann. N.Y. Acad. Sci.660, 88.
Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition. Cold Spring Harbor, NY, p. 1.6, A.6.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogramas

Health hazardCorrosion
GHS08,GHS05

Palabra de señalización

Danger

Frases de peligro

H318,H351,H361fd

Clasificaciones de peligro

Carc. 2 - Eye Dam. 1 - Repr. 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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