208923

CaMKII Inhibitor XII

• Sinónimos: CaMKII Inhibitor XII, Ca ²⁺/Calmodulin-Dependent Protein Kinase II Inhibitor XII
• Fórmula empírica (notación de Hill): C₂₉H₃₀ClN₅O₂S
• Peso molecular: 548.10
• Código UNSPSC: 12352200
• NACRES: NA.28

Propiedades

• Análisis: ≥99% (HPLC)
• Nivel de calidad: 100
• formulario: powder
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white
• solubilidad: DMSO: 100 mg/mL
• Condiciones de envío: wet ice
• temp. de almacenamiento: 2-8°C

Descripción

Descripción general

A pyrimidinyl sulfonamide compound that acts as a potent, reversible and CaM non-competitive inhibitor of CaMKII activities (IC₅₀ = 0.063 µM) with excellent selectivity over several kinases (IC₅₀ = >60, 36, 11, 30 and 21 µM for CaMKIV, MLCK, p38α, Akt1 and PKC, respectively). Shown to exhibit ~25-fold greater potency towards CaMKII than the CaM-competitive inhibitor KN-93 (Cat. No. 422708).

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Asano, S., et al. 2010. Bioorg. Med. Chem. Lett.20, 6696.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable