203995

N-tert-Butyl-α-phenylnitrone

Most commonly-used free radical trap.

• Sinónimos: N-tert-Butyl-α-phenylnitrone, PBN
• Fórmula empírica (notación de Hill): C₁₁H₁₅NO
• Número de CAS: 3376-24-7
• Peso molecular: 177.24
• Número MDL: MFCD00008799
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥98% (GC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• color: white
• solubilidad: DMSO: 10 mg/mL; water: 20 mg/mL; chloroform: 50 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• InChI: 1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3
• Clave InChI: IYSYLWYGCWTJSG-UHFFFAOYSA-N

Descripción

Descripción general

Most commonly used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative diseases. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.

Most commonly-used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
Free radical trap

Product does not compete with ATP.

Reversible: no

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution in DMSO aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 2 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.

Otras notas

Floyd, R.A. 1997. Adv. Pharmacol. 38, 361.
Miyajima, T., and Kotake, Y. 1995. Biochem. Biophys. Res. Commun. 215, 114.
Jazen, E.G., et al. 1994. in Frontiers of Reactive Oxygen Species in Biology and Medicine, (Asada, K., and Yoshikawa, T., eds.), pp. 431-434. Elsevier Science, Amsterdam.
Floyd, R.A. 1990. FASEB J. 4, 2587.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable