203995

N-tert-Butyl-α-phenylnitrone

Most commonly-used free radical trap.

• Sinónimos: N-tert-Butyl-α-phenylnitrone, PBN
• Fórmula empírica (notación de Hill): C₁₁H₁₅NO
• Número CAS: 3376-24-7
• Peso molecular: 177.24
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00008799
• Assay: ≥98% (GC)
• Form: solid
• Storage condition: OK to freeze

Propiedades

• Quality Segment: 100
• assay: ≥98% (GC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: DMSO: 10 mg/mL, water: 20 mg/mL, chloroform: 50 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: [N+](=Cc1ccccc1)([O-])C(C)(C)C
• InChI: 1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3
• InChI key: IYSYLWYGCWTJSG-UHFFFAOYSA-N

Descripción

General description

Most commonly used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative diseases. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.

Most commonly-used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.

Biochem/physiol Actions

Product does not compete with ATP.

Reversible: no

Cell permeable: no

Primary Target
Free radical trap

Preparation Note

Following reconstitution in DMSO aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 2 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.

Other Notes

Floyd, R.A. 1997. Adv. Pharmacol. 38, 361.
Miyajima, T., and Kotake, Y. 1995. Biochem. Biophys. Res. Commun. 215, 114.
Jazen, E.G., et al. 1994. in Frontiers of Reactive Oxygen Species in Biology and Medicine, (Asada, K., and Yoshikawa, T., eds.), pp. 431-434. Elsevier Science, Amsterdam.
Floyd, R.A. 1990. FASEB J. 4, 2587.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable