197900
BEC, Hydrochloride
A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5).
Sinónimos:
BEC, Hydrochloride, (S)-(2-Boronoethyl)-L-cysteine, HCI)
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| A ustedes/SKU | Disponibilidad | Precio |
|---|---|---|
5 mg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 285,00 € |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C5H12BNO4S · xHCl
Peso molecular:
193.03 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥97% (NMR)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
285,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Servicio técnico
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Permítanos ayudarleQuality Segment
assay
≥97% (NMR)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
water: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A boronic acid based arginine analog that acts as a selective, slow- binding, reversible, competitive transition state inhibitor of arginase type I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5). Shown to enhance nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle by inhibiting the activity of arginase. Does not inhibit the activity of nitric oxide synthase (NOS) and may serve as a valuable reagent to probe the physiological relationship between arginase and NOS.
A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5). BEC does not inhibit nitric oxide synthase (NOS). Causes significant enhancement of NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue.
Biochem/physiol Actions
Cell permeable: no
Primary Target
arginase 1, arginase 2
arginase 1, arginase 2
Product does not compete with ATP.
Reversible: no
Target Ki: 310 nM for human recombinant type II arginase, pH 7.5
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot, flush with nitrogen, and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C. After thawing, discard any unused portion.
Other Notes
Colleluori, D.M., and Ash, D.E. 2001. Biochemistry40, 9356.
Kim, N.N., et al. 2001. Biochemistry40, 2678.
Kim, N.N., et al. 2001. Biochemistry40, 2678.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
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Este artículo | |||
|---|---|---|---|
| form solid | form powder | form solid | form crystalline solid |
| assay ≥97% (NMR) | assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥99% (HPLC) |
| manufacturer/tradename Calbiochem® | manufacturer/tradename - | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 10-30°C |
| solubility water: 10 mg/mL | solubility H2O: 20 mg/mL, clear | solubility water: 50 mg/mL | solubility methanol: 10 mg/mL, water: 50 mg/mL |
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
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