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171256

AMPK Activator

The AMPK Activator, also referenced under CAS 849727-81-7, modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

Sinónimos:

AMPK Activator, 5-(3-(4-(2-(4-Fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic acid, D942, AMPK Signaling Activator I

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A ustedes/SKUDisponibilidadPrecio
5 mg
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203,00 €

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Fórmula empírica (notación de Hill):
C22H21FO4
Número CAS:
849727-81-7
Peso molecular:
368.40
MDL number:
MFCD23160261
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light

203,00 €

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Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

light yellow

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Fc1ccc(cc1)CCOc2ccc(cc2)CCCc3[o]c(cc3)C(=O)O

InChI

1S/C22H21FO4/c23-18-8-4-17(5-9-18)14-15-26-19-10-6-16(7-11-19)2-1-3-20-12-13-21(27-20)22(24)25/h4-13H,1-3,14-15H2,(H,24,25)

InChI key

MPLLLQUZNJSVTK-UHFFFAOYSA-N

General description

A cell-permeable furancarboxylic acid compound that activates celular AMP-activated protein kinase (AMPK) activity by inhibiting mitochondrial complex I, and thus elevating intracellular AMP level. Shown to enhance glucose uptake in L6 myocytes (EC50 = 11.7 µM). Reduces blood glucose levels in ZDF rats in vivo (oral dose 30-100 mg/kg). Displays negligible cytotoxicity at pharmacological doses.

Biochem/physiol Actions

Cell permeable: yes
EC50 = 11.7 µM enhancing glucose uptake in L6 myocytes
Primary Target
AMPK
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Kosaka, T., et al. 2005. Anal. Chem.77, 2050.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

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Este artículo
346021550601171260
AMPK Activator The AMPK Activator, also referenced under CAS 849727-81-7, modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

Sigma-Aldrich

171256

AMPK Activator

Glucokinase Activator, Cpd A The Glucokinase Activator, Cpd A, also referenced under CAS 603108-44-7, modulates Glucokinase. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

Sigma-Aldrich

346021

Glucokinase Activator, Cpd A

Pyruvate Kinase Activator The Pyruvate Kinase Activator controls the biological activity of Pyruvate Kinase. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

Sigma-Aldrich

550601

Pyruvate Kinase Activator

AMPK Inhibitor, Compound C AMPK Inhibitor, Compound C, CAS 866405-64-3, is a cell-permeable compound that inhibits KDR/VEGFR2, ALK2/BMPR-I, and AMPK kinase activities (IC50 = 25.1, 148, and 234.6 nM, respectively).

Sigma-Aldrich

171260

AMPK Inhibitor, Compound C

form

solid

form

solid

form

powder

form

solid

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 10 mg/mL

solubility

DMSO: 5 mg/mL

solubility

DMSO: 100 mg/mL, clear, colorless

solubility

2% HCl: 10 mg/mL, 2% acetic acid: 10 mg/mL, methanol: 3 mg/mL, DMSO: 4 mg/mL

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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