169756

Antithrombin III, Human Plasma

Single-chain glycoprotein present in normal serum at about 23 mg/100 ml.

• Sinónimos: Antithrombin III, Human Plasma, ATIII, Heparin cofactor, Factor Xa inhibitor
• Número de CAS: 90170-80-2
• Número MDL: MFCD00166632
• Código UNSPSC: 12352202
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• formulario: solid
• actividad específica: ≥5 units/mg protein
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• solubilidad: water: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C

Descripción

Descripción general

Single chain glycoprotein present in normal serum at about 23 mg/100 ml. Principal physiological inhibitor of thrombin. Present at higher levels in plasma than in serum because it complexes with thrombin during coagulation. Functions by inhibiting proteolytic enzymes involved in blood coagulation and fibrinolysis, including Factor Xa, plasmin, thrombin, and trypsin. Potency is strongly enhanced by heparin.

Single-chain glycoprotein present in normal serum at about 23 mg/100 ml. Principal physiological inhibitor of thrombin. Present at higher levels in plasma than in serum because it complexes with thrombin during coagulation. Functions by inhibiting proteolytic enzymes involved in blood coagulation and fibrinolysis, including Factor Xa, plasmin, thrombin, and trypsin. Potency is strongly enhanced by heparin.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Advertencia

Toxicity: Standard Handling (A)

Definición de unidad

One unit is defined as the amount of antithrombin that will inhibit 1.0 unit of human plasma thrombin present in excess. Thrombin activity is measured using 500 µM tosyl-Gly-Pro-Arg-pNA as substrate in 100 mM Tris-HCl at 25°C, pH 8.2

Forma física

Lyophilized from 100 mM sodium citrate buffer, 20 mM Tris-HCl, pH 8.3.

Nota de preparación

Please refer to label for lot-specific volume prior to lyophilization.

Nota de análisis

single band by SDS-PAGE

Otras notas

Tsiang, M., et al. 1997. J. Biol. Chem. 272, 12024.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable