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164599

Aminopeptidase N, Rat

Name: Aminopeptidase N, Rat
Brand: MM

Sinónimos:

APN/CD13, aminopeptidase N

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Número CE:

3.4.11.2 (BRENDA, IUBMB)

NACRES:

NA.54

UNSPSC Code:

12352202

Specific activity:

≥100 units/mg protein

Assay:

≥90% (SDS-PAGE)

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Propiedades

Quality Segment

100

assay

≥90% (SDS-PAGE)

form

liquid

specific activity

≥100 units/mg protein

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

shipped in

dry ice

storage temp.

−70°C

Descripción

General description

Native aminopeptidase N purified from rat renal brush-border membranes and cleaved with papain to produce soluble enzyme. A single-chain, integral membrane protease that functions to remove N-terminal amino acids from peptides with broad specificity. Aminopeptidase N is believed to play a role in angiogenesis and elevated levels of aminopeptidase N have been reported in patients with various types of cancer and have been correlated with tumor load. Also involved in the final stages of digestion of small peptides in the intestinal brush border.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In 200 mM NaCl, 50 mM Tris-HCl, pH 8.0.

Other Notes

Bhagwat, S.V., et al. 2003. Blood101, 1818.
van Hensbergen, Y., et al. 2002. Clin. Cancer Res.8, 3747.
Ishii, K., et al. 2001. Biol. Pharm. Bull.24, 226.

One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol L-Leu-pNA per min at 37°C, pH 7.2

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Este artículo	407241	164598	324708
Sigma-Aldrich 164599 Aminopeptidase N, Rat	Sigma-Aldrich 407241 Insulin Degrading Enzyme, His•Tag^®, Rat, Recombinant, S. frugiperda	Sigma-Aldrich 164598 Aminopeptidase M, Porcine Kidney	Sigma-Aldrich 324708 Endoproteinase Asp-N, Excision Grade, Pseudomonas fragi
assay ≥90% (SDS-PAGE)	assay ≥90% (SDS-PAGE)	assay -	assay ≥90% (SDS-PAGE)
specific activity ≥100 units/mg protein	specific activity ≥3 units/mg protein	specific activity -	specific activity ≥20,000 units/mg protein
form liquid	form liquid	form suspension (crystalline)	form lyophilized solid
storage condition OK to freeze, avoid repeated freeze/thaw cycles	storage condition OK to freeze	storage condition OK to freeze	storage condition OK to freeze
storage temp. −70°C	storage temp. −70°C	storage temp. 2-8°C	storage temp. 2-8°C
shipped in dry ice	shipped in wet ice	shipped in ambient	shipped in ambient

Clase de almacenamiento

12 - Non Combustible Liquids

wgk

nwg

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