14-936-M

NEK9, active

• Código UNSPSC: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

Propiedades

• recombinante: expressed in baculovirus infected Sf21 cells
• Nivel de calidad: 100
• técnicas: activity assay: suitable
• Nº de acceso UniProt: Q8TD19
• Información sobre el gen: human ... NEK9(91754)

Descripción

Descripción general

Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.

Envase

Also available in 10μg size as catalog # 14-936 and in bulk as catalog # 14-936-K.

Also available in 250μg size as catalog # 14-936M and in bulk as catalog # 14-936-K.

Calidad

Routinely evaluated by phosphorylation of MBP.

Propiedades físicas

41 kDa

Forma física

Protein in 50mM Tris/HCl pH7.5, 300mM NaCl, 20mM β-glycerophosphate, 0.25mM sodium orthovanadate, 10mM NaF, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.

Almacenamiento y estabilidad

6 months at -70°C

Nota de análisis

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H317
• Consejos de prudencia: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Clasificaciones de peligro: Skin Sens. 1
• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2