14-931-M

CaMKK2, active

• Código UNSPSC: 12352200
• eCl@ss: 32160405
• NACRES: NA.41

Propiedades

• origen biológico: human
• Nivel de calidad: 100
• mol peso: M_w 64 kDa
• fabricante / nombre comercial: Upstate^®
• técnicas: activity assay: suitable (kinase)
• Nº de acceso NCBI: NM_172226
• Nº de acceso UniProt: Q96RR4
• Información sobre el gen: human ... CAMKK2(10645)

Descripción

Descripción general

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5′-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca2+ signals. Seems to be involved in hippocampal activation of CREB1. May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.

Product Source: N-terminal 6His-tagged, recombinant, human CaMKK2 full length, expressed by baculovirus in Sf21 insect cells

Envase

Also available in 250μg size as catalog # 14-931M and in bulk as catalog # 14-931-K.

Calidad

Routinely evaluated by phosphorylation of LSNLYHQGKFLQTFCGSPLYRRR

Otras notas

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Información legal

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H317
• Consejos de prudencia: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Clasificaciones de peligro: Skin Sens. 1
• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable