137141

Spermine tetrahydrochloride

EMPROVE^® EVOLVE

• Sinónimos: N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
• Fórmula empírica (notación de Hill): C₁₀H₂₆N₄ · 4HCl
• Número de CAS: 306-67-2
• Peso molecular: 348.18
• Beilstein: 3911771
• Número MDL: MFCD00012914
• Código UNSPSC: 12352116

Propiedades

• origen biológico: synthetic
• Nivel de calidad: 400
• Agency: non-compendial
• formulario: powder
• concentración: 99.0-101.0 % (w/w) (T)
• impurezas: ≤5000 mg/kg ethanol (HS-GC); ≤890 mg/kg toluene (HS-GC)
• mp: 310-311 °C (dec.) (lit.)
• trazas de catión: Al: ≤25 mg/kg; Cr: ≤2.5 mg/kg; Cu: ≤25 mg/kg; Fe: ≤130 mg/kg; Ni: ≤2.5 mg/kg; Zn: ≤130 mg/kg
• idoneidad: corresponds for identity (¹H-NMR)
• aplicaciones: pharma/biopharma processes
• cadena SMILES: Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN
• InChI: 1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
• Clave InChI: XLDKUDAXZWHPFH-UHFFFAOYSA-N

Descripción

Descripción general

Our SAFC^® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

As part of our EMPROVE^® Program, our raw materials are offered with EMPROVE^® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

Aplicación

Used to precipitate DNA from low salt aqueous buffers.

Acciones bioquímicas o fisiológicas

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Información legal

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315 - H319
• Consejos de prudencia: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2
• Código de clase de almacenamiento: 13 - Non Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable