116818

Adenosine 3′,5′-cyclic Monophosphorothioate, 8-Bromo-, Sp-Isomer, Sodium Salt

A potent cell-permeable, metabolically-stable activator of cAMP-dependent protein kinase (PKA).

• Sinónimos: Adenosine 3′,5′-cyclic Monophosphorothioate, 8-Bromo-, Sp-Isomer, Sodium Salt, Sp-8-Br-cAMPS, Na
• Fórmula empírica (notación de Hill): C₁₀H₁₀BrN₅O₅PS · Na
• Peso molecular: 446.15
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Análisis: ≥99% (HPLC)
• formulario: lyophilized
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• solubilidad: water: 40 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C

Descripción

Descripción general

A potent cell-permeable, metabolically stable activator of cAMP-dependent protein kinase (PKA). Induces the guanine-nucleotide-exchange factor activity of GEFI, also known as Epac (exchange protein directly activated by cAMP), and GEFII towards Rap1 both in vivo and in vitro. Significantly more lipophilic and cell permeable than Sp-cAMPS (Cat. No. 116815). λ_max = 264 nm (H₂O, pH 7.0); ε_max = 17,000 M^-1cm^-1. Note: 5 µmol = 2.23 mg.

A potent cell-permeable, metabolically-stable activator of cAMP-dependent protein kinase (PKA). Induces guanine nucleotide exchange factor activity of GEFI (also known as Epac) and GEFII towards Rap1 both in vivo and in vitro. Significantly more lipophilic and cell-permeable than Sp-cAMPS (Cat. No. 116815). Note: 5 µmol = 2.23 mg.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
PKA

Product does not compete with ATP.

Reversible: no

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Kawasaki, H., et al. 1998. Science 282, 2275.
de Rooij, J., et al. 1998. Nature 396, 474.
Holen, I., et al. 1996. Eur. J. Biochem. 236, 163.
Schaap, P., et al. 1993. J. Biol. Chem.268, 6323.
Yokozaki, H., et al. 1992. Cancer Res.52, 2504.

Información legal

Sold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable