07-449-AF647

Anti-trimethyl Histone H3 (Lys27), Alexa Fluor^™ 647 Conjugate Antibody

0.5 mg/mL, from rabbit

• Sinónimos: Histone H3.1t, H3/t, H3t, H3/g
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: ALEXA FLUOR^™ 647
• forma del anticuerpo: purified antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• reactividad de especies: human
• reactividad de especies (predicha por homología): mouse (based on 100% sequence homology)
• concentración: 0.5 mg/mL
• técnicas: immunocytochemistry: suitable
• Nº de acceso NCBI: NM_003493
• Nº de acceso UniProt: Q16695
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: trimethylation (Lys27)
• Información sobre el gen: human ... H3C1(8350) ; mouse ... H3C1(360198)

Descripción

Descripción general

Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. Histone proteins are highly post-translationally modified, and Histone H3 is the most extensively modified of the five histones. Histone H3 sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes. Di- and tri-methylation of histone H3 are gene silencing marks, while removal of these marks by the demethylase genes Jmjd1a and Jmjd2c leads to gene activation. This product is a conjugated version of Cat. No. 07-449.

Inmunógeno

Linear peptide corresponding to Histone H3 trimethylated at Lys27.

Aplicación

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Histones

This Anti-trimethyl Histone H3 (Lys27) antibody is validated for use in ICC for the detection of trimethyl Histone H3 (Lys27).

Calidad

Evaluated by Immunocytochemistry Analysis: in HeLa cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected trimethyl Histone H3 (Lys27) in HeLa cells.

Alexa Fluor^™ is a registered trademark of Life Technologies.

Descripción de destino

~17 kDa observed (Refer to Cat. No. 07-449)

Forma física

Protein A purified

Purified rabbit conjugate antibody in buffer containing PBS and 15 mg/ml BSA with 0.1% Sodium Azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Información legal

ALEXA FLUOR is a trademark of Life Technologies

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable