05-793
Anti-phospho-Estrogen Receptor alpha (Ser118) Antibody, clone NL44, rabbit monoclonal
clone NL44, Upstate®, from rabbit
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Productos recomendados
origen biológico
rabbit
Nivel de calidad
forma del anticuerpo
purified antibody
tipo de anticuerpo
primary antibodies
clon
NL44, monoclonal
reactividad de especies
human
fabricante / nombre comercial
Upstate®
técnicas
western blot: suitable
isotipo
IgG
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
dry ice
modificación del objetivo postraduccional
phosphorylation (pSer118)
Información sobre el gen
human ... ESR1(2099)
Especificidad
Predicted to cross-react with camel, mouse, pig and Syrian hamster based on sequence homology
phospho-estrogen receptor a (Ser118)
Inmunógeno
Peptide containing the sequence QLpSPF in which pS corresponds to phosphoserine at residue 118 of human estrogen receptor alpha
Aplicación
Anti-phospho-Estrogen Receptor alpha (Ser118) Antibody, clone NL44 is a Rabbit Monoclonal Antibody for detection of ER alpha also known as Estrogen receptor alpha & has been tested in WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Calidad
routinely evaluated by immunoblot on RIPA lysates from MCF-7 cells treated with estradiol and EGF, and recombinant estrogen receptor alpha phosphorylated in vitro with MAP Kinase 2/Erk2, active (Catalog #14-173)
Descripción de destino
~66kDa
Forma física
0.2M Tris-glycine, pH 7.4, 0.15M NaCl, 100mM EDTA, 0.05% sodium azide, before the addition of glycerol to 30%
Format: Purified
Protein A purified
Almacenamiento y estabilidad
2 years at -20°C
Información legal
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Dongsheng Chen et al.
Oncogene, 21(32), 4921-4931 (2002-07-16)
Estrogen receptor alpha (ERalpha) is a transcription factor that regulates expression of target genes in a ligand-dependent manner. Activation of gene expression is mediated by two transcription activation functions AF-1 and AF-2, which act in a promoter- and cell-specific manner.
Estradiol-induced phosphorylation of serine 118 in the estrogen receptor is independent of p42/p44 mitogen-activated protein kinase.
Joel, P B, et al.
The Journal of Biological Chemistry, 273, 13317-13323 (1998)
Yue Xue et al.
Molecular cancer research : MCR, 17(1), 238-249 (2018-09-13)
The presence of cancer stem cells (CSC), which possess the ability of self-renewal and cancer initiation, is correlated with poor prognosis and drug resistance of breast cancer patients. But the molecular regulatory networks for maintenance of CSC function still remain
Ze-Yi Zheng et al.
Cancer cell, 37(3), 387-402 (2020-03-07)
We report that neurofibromin, a tumor suppressor and Ras-GAP (GTPase-activating protein), is also an estrogen receptor-α (ER) transcriptional co-repressor through leucine/isoleucine-rich motifs that are functionally independent of GAP activity. GAP activity, in turn, does not affect ER binding. Consequently, neurofibromin
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