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Merck

850151P

Avanti

18:1 PI(4)P

Avanti Research - A Croda Brand 850151P, powder

Sinónimos:

1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′-phosphate) (ammonium salt)

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About This Item

Fórmula empírica (notación de Hill):
C45H90N2O16P2
Número de CAS:
Peso molecular:
977.15
Código UNSPSC:
51191904
NACRES:
NA.25

Análisis

>99% (TLC)

formulario

powder

envase

pkg of 1 × 100 μg (with stopper and crimp cap (850151P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850151P-500ug))

fabricante / nombre comercial

Avanti Research - A Croda Brand 850151P

tipo de lípido

cardiolipins
phospholipids

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

cadena SMILES

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+].[NH4+]

Descripción general

18:1 PI(5)P (1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′-phosphate) is an ammonium salt of modified lipid which bears a double at the 9th carbon of dioleoyl group. Phosphatidylinositol 4-phosphate (PI-4-P) is an abundant phosphoinositide species present in the plasma membrane.
Inositol phospholipid species are membrane-bound signaling molecules that have been implicated in almost all aspects of cellular physiology, including cellular growth, metabolism, proliferation, and survival.

Aplicación

18:1 PI(5)P (1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′-phosphate) (ammonium salt)) has been used in protein−lipid overlay assay. It may be used in small unilamellar vesicles for liposome flotation assays. It may also be used in different lipid binding specificity studies.

Acciones bioquímicas o fisiológicas

Phosphatidylinositol 4-phosphate (PI-4-P) is an important factor, that is required for membrane traffic, polarized growth and cytoskeleton organization.

Envase

2 mL Amber Serum Vial with Stopper and Crimp Cap (850151P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850151P-500ug)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

No data available

Punto de inflamabilidad (°C)

No data available


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Los clientes también vieron

Vikram Ghugtyal et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(28), 8644-8649 (2015-07-01)
The phospholipid phosphatidylinositol-4-phosphate [PI(4)P], generated at the Golgi and plasma membrane, has been implicated in many processes, including membrane traffic, yet its role in cell morphology changes, such as the budding to filamentous growth transition, is unknown. We show that
Carolyn M Shirey et al.
Analytical biochemistry, 516, 9-12 (2016-10-28)
To reduce costs of lipid-binding assays, allow for multiple lipids to be screened for protein binding simultaneously, and to make lipid binding more user friendly, lipids have been dotted onto membranes to investigate lipid-protein interactions. These assays are similar to
Chao-Yuan Yu et al.
Plant physiology, 183(1), 221-235 (2020-03-25)
Phosphoinositides function as lipid signals in plant development and stress tolerance by binding with partner proteins. We previously reported that Arabidopsis (Arabidopsis thaliana) phosphoinositide-specific phospholipase C2 functions in the endoplasmic reticulum (ER) stress response. However, the underlying molecular mechanisms of
Mark R Lundquist et al.
Molecular cell, 70(3), 531-544 (2018-05-05)
While the majority of phosphatidylinositol-4, 5-bisphosphate (PI-4, 5-P2) in mammalian cells is generated by the conversion of phosphatidylinositol-4-phosphate (PI-4-P) to PI-4, 5-P2, a small fraction can be made by phosphorylating phosphatidylinositol-5-phosphate (PI-5-P). The physiological relevance of this second pathway is
Lee Dolat et al.
The Journal of cell biology, 214(5), 517-527 (2016-08-24)
Macropinocytosis, the internalization of extracellular fluid and material by plasma membrane ruffles, is critical for antigen presentation, cell metabolism, and signaling. Macropinosomes mature through homotypic and heterotypic fusion with endosomes and ultimately merge with lysosomes. The molecular underpinnings of this

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