920517

6-(4-(tert-Butoxycarbonyl)-1,4-diazepan-1-yl)pyrazine-2-carboxylic acid

• Sinónimos: Rigid linker for PROTAC^® development
• Fórmula empírica (notación de Hill): C₁₅H₂₂N₄O₄
• Número de CAS: 1700483-37-9
• Peso molecular: 322.36
• Código UNSPSC: 12352106
• NACRES: NA.22

Propiedades

• idoneidad de la reacción: reagent type: linker
• Nivel de calidad: 100
• grupo funcional: Boc; carboxylic acid
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CC(C)(OC(N1CCCN(C2=CN=CC(C(O)=O)=N2)CC1)=O)C

Descripción

Aplicación

6-(4-(tert-Butoxycarbonyl)-1,4-diazepan-1-yl)pyrazine-2-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920525
920681

Otras notas

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Información legal

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable