122912
2-Amino-6,8-dihydroxypurine
Sinónimos:
2-Amino-6,8-purinediol, 8-Hydroxyguanine
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About This Item
Fórmula empírica (notación de Hill):
C5H5N5O2
Número de CAS:
Peso molecular:
167.13
Número CE:
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
Productos recomendados
impurezas
<10% acetic acid
cadena SMILES
Nc1nc(O)c2[nH]c(O)nc2n1
InChI
1S/C5H5N5O2/c6-4-8-2-1(3(11)10-4)7-5(12)9-2/h(H5,6,7,8,9,10,11,12)
Clave InChI
CLGFIVUFZRGQRP-UHFFFAOYSA-N
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Órganos de actuación
Respiratory system
Código de clase de almacenamiento
13 - Non Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
235.4 °F - closed cup
Punto de inflamabilidad (°C)
113 °C - closed cup
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Sara Timpano et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(4), 5716-5728 (2019-01-17)
Multicellular organisms balance oxygen delivery and toxicity by having oxygen pass through several barriers before cellular delivery. In human cell culture, these physiologic barriers are removed, exposing cells to higher oxygen levels. Human cells cultured in ambient air may appear
Eleonora Parlanti et al.
Free radical biology & medicine, 53(11), 2171-2177 (2012-09-27)
Although oxidatively damaged DNA is repaired primarily via the base excision repair (BER) pathway, it is now evident that multiple subpathways are needed. Yet, their relative contributions and coordination are still unclear. Here, mouse embryo fibroblasts (MEFs) from selected nucleotide
Alexandra A Kuznetsova et al.
Biochimica et biophysica acta, 1840(1), 387-395 (2013-10-08)
Extensive structural studies of human DNA glycosylase hOGG1 have revealed essential conformational changes of the enzyme. However, at present there is little information about the time scale of the rearrangements of the protein structure as well as the dynamic behavior
Peter German et al.
DNA repair, 12(10), 856-863 (2013-07-31)
Accumulation of 8-oxo-7,8-dihydroguanine (8-oxoG) in the DNA results in genetic instability and mutagenesis, and is believed to contribute to carcinogenesis, aging processes and various aging-related diseases. 8-OxoG is removed from the DNA via DNA base excision repair (BER), initiated by
Nozomi Nakanishi et al.
Mutagenesis, 28(1), 117-123 (2012-10-12)
Oxidative DNA lesions inhibit the transcription of RNA polymerase II, but in the presence of transcription elongation factors, the transcription can bypass the lesions. Single-subunit mitochondrial RNA polymerase (mtRNAP) catalyses the synthesis of essential transcripts in mitochondria where reactive oxidative
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