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Merck

NCF4

neutrophil cytosolic factor 4, 40kDa

Sinónimos:
NCF, P40PHOX, SH3PXD4
Especie:
ID UniProtKB:
ID del gen:
  • Human(4689) Summary: The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
  • Mouse(17972) neutrophil cytosolic factor 4
  • Rat(500904) neutrophil cytosolic factor 4
  • chicken(418052) neutrophil cytosolic factor 4, 40kDa
  • Zebrafish(403014) neutrophil cytosolic factor 4
  • domestic cat(101095507) neutrophil cytosolic factor 4, 40kDa
  • dog(481277) neutrophil cytosolic factor 4, 40kDa
  • cow(507859) neutrophil cytosolic factor 4, 40kDa
  • Horse(100069566) neutrophil cytosolic factor 4, 40kDa
  • sheep(101122939) neutrophil cytosolic factor 4, 40kDa
  • Domestic Rabbit(100009359) neutrophil cytosolic factor 4, 40kDa
  • domestic guinea pig(100729267) neutrophil cytosolic factor 4, 40kDa
  • naked mole-rat(101699188) neutrophil cytosolic factor 4, 40kDa

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-NCF4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
Anti-NCF4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunofluorescence
Anti-NCF4 antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
guinea pig, horse, human, rat
Aplicación
western blot
Anti-NCF4 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
western blot
Anti-NCF4/p40-phox Antibody, clone 4L9Z4, Rabbit Monoclonal, ,
Reactividad de especies
mouse
Aplicación
immunohistochemistry
immunoprecipitation (IP)

western blot

Proteins

Referencia del producto
Descripción
Especie
Cytosol from Liver, Pooled, from human,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting human NCF4,
Especie
human
MISSION® esiRNA, targeting mouse Ncf4,
Especie
mouse