MECP2
methyl CpG binding protein 2 (Rett syndrome)
Sinónimos:
AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT
Especie:
Human MECP2 (4204), Mouse Mecp2 (17257), Rat Mecp2 (29386), domestic cat MECP2 (101082385), Zebrafish mecp2 (335250), Domestic Rabbit MECP2 (100328751), dog MECP2 (612973), domestic guinea pig Mecp2 (100734864), sheep MECP2 (101121154), naked mole-rat Mecp2 (101700584)
ID UniProtKB:
ID del gen:
- Human(4204) Summary: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. [provided by RefSeq, Jul 2009]
- Mouse(17257) methyl CpG binding protein 2
- Rat(29386) methyl CpG binding protein 2
- domestic cat(101082385) methyl CpG binding protein 2 (Rett syndrome)
- Zebrafish(335250) methyl CpG binding protein 2
- Domestic Rabbit(100328751) methyl CpG binding protein 2 (Rett syndrome)
- dog(612973) methyl CpG binding protein 2 (Rett syndrome)
- domestic guinea pig(100734864) methyl CpG binding protein 2 (Rett syndrome)
- sheep(101121154) methyl CpG binding protein 2 (Rett syndrome)
- naked mole-rat(101700584) methyl CpG binding protein 2 (Rett syndrome)
- cow(539629) methyl CpG binding protein 2 (Rett syndrome)
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Monoclonal Anti-MECP2 antibody produced in mouse, clone 4B6, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
mouse
Aplicación
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-MeCP2, from rabbit, purified by affinity chromatography,
Reactividad de especies
bovine, human, mouse, rat, rhesus macaque
Aplicación
immunofluorescence
western blot
western blot
Anti-MECP2 antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
immunohistochemistry
Monoclonal Anti-MECP2 antibody produced in mouse, clone 1B11, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-MECP2 antibody produced in rabbit, Ab2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
Proteins
Referencia del producto
Descripción
Especie