MCM4
minichromosome maintenance complex component 4
Sinónimos:
CDC21, CDC54, NKCD, NKGCD, P1-CDC21, hCdc21
Especie:
Human MCM4 (4173), Mouse Mcm4 (17217), Rat Mcm4 (29728), Thale Cress MCM4 (816142), Zebrafish mcm4 (337598), domestic guinea pig Mcm4 (100724549), naked mole-rat Mcm4 (101721409), domestic cat MCM4 (101089576), sheep MCM4 (101105420), cow MCM4 (504367) ...Más
ID UniProtKB:
ID del gen:
- Human(4173) Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
- Mouse(17217) minichromosome maintenance deficient 4 homolog (S. cerevisiae)
- Rat(29728) minichromosome maintenance complex component 4
- Thale Cress(816142) minichromosome maintenance protein 4
- Zebrafish(337598) MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae)
- domestic guinea pig(100724549) minichromosome maintenance complex component 4
- naked mole-rat(101721409) minichromosome maintenance complex component 4
- domestic cat(101089576) minichromosome maintenance complex component 4
- sheep(101105420) minichromosome maintenance complex component 4
- cow(504367) minichromosome maintenance complex component 4
- dog(477871) minichromosome maintenance complex component 4
- Horse(100051303) minichromosome maintenance complex component 4
- chicken(426764) minichromosome maintenance complex component 4
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-MCM4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-MCM4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunofluorescence
western blot
western blot
Monoclonal Anti-MCM4 antibody produced in mouse, clone 1A6, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
ELISA
Anti-MCM4 Antibody, clone 5N0X3, Rabbit Monoclonal, ,
Reactividad de especies
human, rat
Aplicación
western blot
Rabbit anti-MCM4 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Reactividad de especies
human, mouse
Aplicación
immunohistochemistry
western blot
western blot