LRP2
low density lipoprotein receptor-related protein 2
Sinónimos:
DBS, GP330
Especie:
Human LRP2 (4036), Mouse Lrp2 (14725), Rat Lrp2 (29216), domestic guinea pig Lrp2 (100713603), naked mole-rat Lrp2 (101717800), domestic cat LRP2 (101087337), Horse LRP2 (100062836), cow LRP2 (100337021), dog LRP2 (478781), Domestic Rabbit LRP2 (100346275) ...Más
ID UniProtKB:
ID del gen:
- Human(4036) Summary: The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]
- Mouse(14725) low density lipoprotein receptor-related protein 2
- Rat(29216) low density lipoprotein receptor-related protein 2
- domestic guinea pig(100713603) low density lipoprotein receptor-related protein 2
- naked mole-rat(101717800) low density lipoprotein receptor-related protein 2
- domestic cat(101087337) low density lipoprotein receptor-related protein 2
- Horse(100062836) low density lipoprotein receptor-related protein 2
- cow(100337021) low density lipoprotein receptor-related protein 2
- dog(478781) low density lipoprotein receptor-related protein 2
- Domestic Rabbit(100346275) low density lipoprotein receptor-related protein 2
- sheep(101108200) low density lipoprotein receptor-related protein 2
- chicken(424168) low density lipoprotein receptor-related protein 2
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-LRP-2/Megalin Antibody, clone 10D5.1, clone 10D5.1, from mouse,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
western blot
Anti-LRP2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
Anti-LRP2 Antibody, clone 1I21 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, monkey
Aplicación
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-LRP2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
ANTI-LRP2 (MEGALIN) (C-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Reactividad de especies
human
Aplicación
ELISA
immunohistochemistry
immunohistochemistry