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Merck

IMPDH2

IMP (inosine 5'-monophosphate) dehydrogenase 2

Sinónimos:
IMPD2, IMPDH-II
Especie:
Human IMPDH2 (3615), Mouse Impdh2 (23918), Rat Impdh2 (301005), dog IMPDH2 (476630), Zebrafish impdh2 (317745), domestic guinea pig Impdh2 (100730768), naked mole-rat Impdh2 (101701391), domestic cat IMPDH2 (101080693), cow IMPDH2 (511969), sheep IMPDH2 (101107823) ...Más
ID UniProtKB:
P12268, Q6LEF3
ID del gen:
  • Human(3615) Summary: This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
  • Mouse(23918) inosine 5'-phosphate dehydrogenase 2
  • Rat(301005) IMP (inosine 5'-monophosphate) dehydrogenase 2
  • dog(476630) IMP (inosine 5'-monophosphate) dehydrogenase 2
  • Zebrafish(317745) IMP (inosine monophosphate) dehydrogenase 2
  • domestic guinea pig(100730768) IMP (inosine 5'-monophosphate) dehydrogenase 2
  • naked mole-rat(101701391) IMP (inosine 5'-monophosphate) dehydrogenase 2
  • domestic cat(101080693) IMP (inosine 5'-monophosphate) dehydrogenase 2
  • cow(511969) IMP (inosine 5'-monophosphate) dehydrogenase 2
  • sheep(101107823) IMP (inosine 5'-monophosphate) dehydrogenase 2
  • Domestic Rabbit(100355621) IMP (inosine 5'-monophosphate) dehydrogenase 2
  • chicken(416058) IMP (inosine 5'-monophosphate) dehydrogenase 2
  • Horse(100063255) IMP (inosine 5'-monophosphate) dehydrogenase 2

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
HPA001400
Anti-IMPDH2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
western blot
ST1578
Anti-IMPDH2 Mouse mAb (1E12-B6), liquid, clone 1E12-B6, Calbiochem®,
Reactividad de especies
human
Aplicación
WH0003615M1
Monoclonal Anti-IMPDH2 antibody produced in mouse, clone 1E12-B6, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
ELISA
immunoprecipitation (IP)
western blot
SAB1410715
Anti-IMPDH2 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
immunofluorescence
western blot
SAB1406037
Anti-IMPDH2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
western blot

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
N4505
β-Nicotinamide adenine dinucleotide, reduced dipotassium salt, ,
Especie
human
A4882
6-Thioguanine, ≥98%,
Especie
human
M5255
Mycophenolic acid, ≥98%,
Especie
human
R9644
Ribavirin, antiviral,
Especie
human
M3536
Mycophenolic acid, powder, BioReagent, suitable for cell culture,
Especie
human

Proteins

Referencia del producto
Descripción
Especie
I1782
Inosine Monophosphate Dehydrogenase Type II human, recombinant, expressed in E. coli,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
EHU027541
MISSION® esiRNA, targeting human IMPDH2,
Especie
human
EMU094871
MISSION® esiRNA, targeting mouse Impdh2,
Especie
mouse