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Merck

ADRA2C

adrenoceptor alpha 2C

Sinónimos:
ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR
Especie:
ID UniProtKB:
ID del gen:
  • Human(152) Summary: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
  • Mouse(11553) adrenergic receptor, alpha 2c
  • Rat(24175) adrenoceptor alpha 2C
  • domestic guinea pig(100135477) adrenergic receptor, alpha 2c
  • domestic guinea pig(101787589) adrenoceptor alpha 2C
  • cow(101902575) adrenoceptor alpha 2C
  • cow(407139) alpha-2C adrenergic receptor
  • sheep(100170319) adrenoceptor alpha 2C
  • Zebrafish(266752) adrenergic, alpha-2C-, receptor
  • chicken(428799) adrenergic, alpha-2C-, receptor
  • dog(488793) adrenoceptor alpha 2C
  • domestic cat(101087990) adrenoceptor alpha 2C
  • domestic cat(100529244) adrenoceptor alpha 2C

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Small Molecule - Agonist

Referencia del producto
Descripción
Especie
Clonidine hydrochloride, solid,
Especie
human
Xylazine hydrochloride, ≥99.0% (HPLC),
Especie
human
Guanfacine hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Especie
human
Guanfacine hydrochloride, ≥98% (HPLC),
Especie
human
Guanabenz acetate salt, powder,
Especie
human

Small Molecule - Antagonist

Referencia del producto
Descripción
Especie
Yohimbine hydrochloride, ≥98% (HPLC), powder,
Especie
human
Idazoxan hydrochloride, ,
Especie
human
RX 821002 hydrochloride, solid, ≥98% (HPLC),
Especie
human
UK 14,304, ,
Especie
human
Mirtazapine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Especie
human

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Monoclonal Anti-Alpha 2C Adrenergic Receptor - Apc antibody produced in mouse, clone S330A-80, purified immunoglobulin,
Reactividad de especies
human, mouse
Aplicación
immunocytochemistry
western blot
Anti-Adrenergic Receptor α-2C antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
western blot
Monoclonal Anti-Alpha 2C Adrenergic Receptor - Atto 390 antibody produced in mouse, clone S330A-80, purified immunoglobulin,
Reactividad de especies
human, mouse
Aplicación
immunocytochemistry
western blot
Monoclonal Anti-Alpha 2C Adrenergic Receptor - Atto 488 antibody produced in mouse, clone S330A-80, purified immunoglobulin,
Reactividad de especies
human, mouse
Aplicación
immunocytochemistry
western blot
Monoclonal Anti-Alpha 2C Adrenergic Receptor - Rpe antibody produced in mouse, clone S330A-80, purified immunoglobulin,
Reactividad de especies
human, mouse
Aplicación
immunocytochemistry
western blot

Small Molecule - Blocker

Referencia del producto
Descripción
Especie
Mianserin hydrochloride, ,
Especie
human
Agmatine sulfate salt, ≥97%, powder,
Especie
human

Small Molecule - Mixed Agonist/Antagonist

Referencia del producto
Descripción
Especie
UK 14,304, ,
Especie
human
(−)-Norepinephrine, ≥98%, crystalline,
Especie
human, rat
Haloperidol, powder,
Especie
human, rat
Clozapine, ,
Especie
human, rat

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting mouse Adra2c,
Especie
mouse