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Merck

ABCC2

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

Sinónimos:
ABC30, CMOAT, DJS, MRP2, cMRP
Especie:
Human ABCC2 (1244), Mouse Abcc2 (12780), Rat Abcc2 (25303), sheep ABCC2 (101119776), Horse ABCC2 (100060654), naked mole-rat Abcc2 (101716089), domestic guinea pig Abcc2 (100718828), cow ABCC2 (520925), domestic cat ABCC2 (101085924), dog ABCC2 (403632) ...Más
ID UniProtKB:
Q92887, B2RMT8, Q14022, Q5T2B1, Q92500, Q92798, Q99663, Q9UMS2
ID del gen:
  • Human(1244) Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
  • Mouse(12780) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • Rat(25303) ATP-binding cassette, subfamily C (CFTR/MRP), member 2
  • sheep(101119776) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • Horse(100060654) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • naked mole-rat(101716089) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • domestic guinea pig(100718828) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • cow(520925) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • domestic cat(101085924) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • dog(403632) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • chicken(423828) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • Zebrafish(393561) ATP-binding cassette, sub-family C (CFTR/MRP), member 2

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
ZRB2029
Anti-MRP2 Antibody, clone 1B2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, monkey
Aplicación
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
MAB4150
Anti-MRP2 Antibody, CT, clone M2 III-6, culture supernatant, clone M2 III-6, Chemicon®,
Reactividad de especies
human
Aplicación
immunocytochemistry
immunohistochemistry
western blot
HPA071145
Anti-ABCC2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
MAB4148
Anti-MRP2 Antibody, clone M2 I-4, culture supernatant, clone M2 I-4, Chemicon®,
Reactividad de especies
human
Aplicación
immunocytochemistry
immunohistochemistry
western blot
M3692
Anti-MRP2 antibody, Mouse monoclonal, clone CPR96, purified from hybridoma cell culture,
Reactividad de especies
human
Aplicación
ELISA
microarray
western blot

Kits

Referencia del producto
Descripción
Especie
MAK161
Multidrug Resistance Assay Kit, (Fluorometric MDR Assay),
Especie
human, mouse, rat

esiRNA

Referencia del producto
Descripción
Especie
EHU052041
MISSION® esiRNA, targeting human ABCC2,
Especie
human