T7540
Tyrphostin 47
≥98%
Synonym(s):
α-Cyano-3,4-dihydroxythiocinnamamide, 3,4-Dihydroxy-α-cyanothiocinnamamide, RG 50864
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About This Item
Empirical Formula (Hill Notation):
C10H8N2O2S
CAS Number:
Molecular Weight:
220.25
Beilstein:
6508337
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥98%
potency
2.4 μM IC50
solubility
DMSO: soluble 50 mg/mL, clear, orange
ethanol: soluble
storage temp.
2-8°C
SMILES string
NC(=S)\C(=C\c1ccc(O)c(O)c1)C#N
Gene Information
human ... CDK2(1017) , EGFR(1956)
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Application
Tyrphostin 47 has been used in LOPAC screening assays to identify human tissue transglutaminase (TGM2) inhibitors. Tyrphostin 47 has also been used to study its effects on hyperpolarization-activated cation current in porcine pacemaker cells.
Biochem/physiol Actions
Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.
EGFR tyrosine kinase inhibitor.
Preparation Note
Tyrphostin 47 is is soluble in DMSO (50 mg/ml) and yields a clear, orange solution. The product is also soluble in ethanol (40 mM).
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Jun Takeda et al.
Development, growth & differentiation, 44(6), 501-508 (2002-12-21)
During the development of the chicken proventriculus (glandular stomach), the initially undifferentiated epithelium differentiates into two distinct cell populations: the glandular epithelium, cells of which secrete embryonic chicken pepsinogen (ECPg), and luminal epithelial cells, which express the chicken spasmolytic polypeptide
Maribel Diaz-Ricart et al.
Thrombosis research, 121(6), 873-883 (2007-10-02)
Platelet activation leads to signal transduction mechanisms, in which phosphotyrosine proteins play a relevant role. Platelet suspensions were independently activated by collagen and thrombin in the absence and in the presence of two tyrosine kinase inhibitors, tyrphostin 47 and genistein.
Naoki Kimura et al.
Bioconjugate chemistry, 18(6), 1778-1785 (2007-10-24)
The present study reported proof-of-principle for a kinase assay approach that can detect specific peptide phosphorylation events. The method involves attachment of peptides onto commercial aminosilane and polycarbodiimide-coated glass slides, using a newly developed DNattach linker system that consists of
Yorimasa Ogata et al.
Cell biology international, 27(8), 689-693 (2003-07-18)
Bradykinin (1 microM) and histamine (100 microM) evoked an initial transient increase and a subsequent sustained increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in fura-2-loaded human gingival fibroblasts, which may be attributed to Ca(2+) release from intracellular stores and Ca(2+) entry
[Stimulating effect of insulin and epidermal growth factor on activity of protein kinase A, glucose 6-phosphate dehydrogenase and glycogen synthetase in skeletal muscles of chickens and chicken embryos].
L A Kuznetsova et al.
Zhurnal evoliutsionnoi biokhimii i fiziologii, 40(4), 325-333 (2004-10-16)
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