SML2123
BRF110
≥98% (HPLC)
Synonym(s):
4-[Methyl[2-phenyl-5-(2-propen-1-yl)-6-(trifluoromethyl)-4-pyrimidinyl]amino]benzoic acid
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About This Item
Empirical Formula (Hill Notation):
C22H18F3N3O2
CAS Number:
Molecular Weight:
413.39
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(C1=CC=C(N(C2=NC(C3=CC=CC=C3)=NC(C(F)(F)F)=C2CC=C)C)C=C1)O
Biochem/physiol Actions
BRF110 is a brain penetrant, potent and selective agonist of nuclear receptor-related 1 (Nurr1):Retinoid X receptor α (RXRα) heterodimer. BRF110 is a neuroprotective agent that prevents dopaminergic neuron demise and striatal dopaminergic denervation in vivo against PD-causing toxins. It induced dopamine biosynthesis in vivo. BRF110 chronic dosing does not induce dyskinesia in mice model.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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