SAB4504176

Anti-phospho-ERK8 (pThr¹⁷⁵+Tyr¹⁷⁷) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): ERK7, MAPK15
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 59 kDa
• species reactivity: human, mouse, rat
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:5000; western blot: 1:500-1:1000
• NCBI accession no.: Q8TD08
• UniProt accession no.: Q8TD08
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pThr175+pTyr177)
• Gene Information: human ... MAPK15(225689)

Description

General description

Mitogen-activated protein (MAP) kinase 15 (MAPK15) or extracellular signal-regulated kinase 8 (ERK8) belongs to the MAP kinase family. MAPK15 gene is located on human chromosome 8q24.3.

Immunogen

The antiserum was produced against synthesized peptide derived from human ERK8 around the phosphorylation site of Thr175 and Tyr177.

Immunogen Range: 141-190

Biochem/physiol Actions

Extracellular signal-regulated kinase 8 (ERK8)/mitogen-activated protein (MAP) kinase 15 aids in maintaining the integrity of the genome. Anaplastic thyroid carcinoma cells show high expression of MAPK15. It controls telomerase reverse transcriptase (hTERT) mRNA expression to regulate telomerase activity. It is highly essential to control the generation of reactive oxygen species. MAPK15 also plays a role in stabilizing proliferating cell nuclear antigen protein. MAPK15 might be involved in the progression of human cancer. Hence it might act as a candidate as an attractive target for cancer therapy.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable