MPC1 (mitochondrial pyruvate carrier 1) gene is mapped to human chromosome 6q27. MPC1 encodes a 12kDa, protein containing five exons and two membrane spanning α helixes. Anti-BRP44L Antibody detects endogenous levels of total BRP44L protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human BRP44L.
Immunogen Range: 11-60
Application
Anti-BRP44L antibody produced in rabbit has been used to check the effect of mitochondrial TOM70 (translocase of the outer membrane protein 70) on MPC1 (mitochondrial pyruvate carrier 1) expression.
Biochem/physiol Actions
MPC1 (mitochondrial pyruvate carrier 1) is a key player in pyruvate metabolism. It transports pyruvate into the inner mitochondrial matrix. Lowered MPC1 expression, elevates glycolysis due to a shift in metabolism to fatty acid oxidation. This accounts for the pathogenesis of cancer and other diseases. Downregulation of this gene is observed in colon adenocarcinoma.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC)
Sandoval IT, et al.
eLife, 6(28), e22706-e22706 (2017)
TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer
Filadi R, et al.
Current Biology, 28(3), 369-382 (2018)
Defective expression of the mitochondrial-trna modifying enzyme GTPBP3 triggers AMPK-mediated adaptive responses involving complex I assembly factors, uncoupling protein 2, and the mitochondrial pyruvate carrier
Martinez-Zamora A, et al.
PLoS ONE, 10(12), e0144273-e0144273 (2015)
Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells
Li X, et al.
Testing, 8(28), 46363-46363 (2017)
Mitochondrial pyruvate carrier function is negatively linked to Warburg phenotype in vitro and malignant features in esophageal squamous cell carcinomas
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