Cathepsin S (CTSS; EC 3.4.22.27) is a lysosomal cysteine proteinase involved in the degradation of proteins to peptides required for the presentation of MHC class II molecules.1 It is associated with pathological conditions such as atherosclerosis, coronary heart disease, cancer, and insulin resistance.
Suitability
Suitable for the screening of inhibitors of Cathepsin S.
Principle
The Cathepsin S Inhibitor Screening Kit is a simple assay for screening potential inhibitors of CTSS. CTSS activity is measured by cleaving a synthetic 7-amino-4-trifluoromethylcoumarin (AFC)-based substrate to yield AFC, a fluorescent product (λex = 400/ λem = 505 nm), proportional to the enzymatic activity present.
Kit Components Only
Product No.
Description
CTSS Reaction Buffer
Cathepsin S, human
CTSS Substrate, Z-VVR-AFC, 10 mM
CTSS Inhibitor Z-FF-FMK, 1 mM
Storage Class Code
10 - Combustible liquids
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
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