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M4008

Sigma-Aldrich

Morin hydrate

powder

Synonym(s):

2′,3,4′,5,7-Pentahydroxyflavone

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About This Item

Empirical Formula (Hill Notation):
C15H10O7 · xH2O
CAS Number:
654055-01-3
Molecular Weight:
302.24 (anhydrous basis)
EC Number:
207-542-9
MDL number:
MFCD00217054
UNSPSC Code:
12171500
PubChem Substance ID:
24278552
NACRES:
NA.77

form

powder

color

yellow

solubility

methanol: 50 mg/mL

SMILES string

O.Oc1ccc(c(O)c1)C2=C(O)C(=O)c3c(O)cc(O)cc3O2

InChI

1S/C15H10O7.H2O/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15;/h1-5,16-19,21H;1H2

InChI key

MYUBTSPIIFYCIU-UHFFFAOYSA-N

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Application

Morin hydrate has been used:
  • to investigate its antitumor functionality using cell viability and apoptosis assay in human cancer cell lines.
  • as a fluorescence stain to detect aluminum in motor neurons and lumbar cord.
  • to study its protective effect on neuronal hearing loss and on neural stem cells (NSCs) proliferation and differentiation

Biochem/physiol Actions

Morin hydrate is a flavonoid with antioxidant properties. It has been shown to protect cells against oxygen radical damage. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase, a free-radical generating enzyme. At concentrations of 75-100 micromolar, morin inhibits oxidation of low density lipoprotein (LDL) by free radicals or Cu2+. Morin has been reported to inhibit rat brain phospha­tidyl­inositol­phos­phate kinase activity in vitro and in vivo.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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T W Wu et al.
Life sciences, 57(3), PL51-PL56 (1995-01-01)
Oxidative modification of low density lipoprotein (LDL) has been suggested to be a risk factor for the development of atherosclerosis. Agents which can protect LDL from oxidation may be useful in preventing atherogenesis. Here, we found that morin hydrate, at
L H Zeng et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 75(6), 717-720 (1997-01-01)
Oxygen-derived free radicals are known to injure the endothelium of aorta in diverse disorders. In this study we compared the cytoprotective effects of three flavonoids against oxyradical damage to porcine aortic endothelial cells in vitro. Cultured porcine aortic endothelial cells
L H Zeng et al.
Life sciences, 55(18), PL351-PL357 (1994-01-01)
Cultured rat glomerular mesangial cells were damaged when exposed to oxyradicals generated either from xanthine oxidase plus hypoxanthine, or by superoxide radicals formed from menadione. Morin hydrate is an antioxidant extracted from yellow Brazil wood. When morin hydrate was added
Shan Yu et al.
Inflammation, 43(4), 1293-1303 (2020-03-07)
Mastitis is one of the most common diseases that both affects human and animals. Morin is derived from the member of Moraceae family, which has been used in the treatment of many inflammatory diseases. The purpose of this study was
Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration
Shaw CA and Petrik MS
Journal of Inorganic Biochemistry, 103(11), 1555-1562 (2009)
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Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

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