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M3324

Sigma-Aldrich

M100907

≥98% (HPLC)

Synonym(s):

(R)-(+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol, MDL100907, Volinanserin

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5 MG
€156.00
25 MG
€619.00

€156.00

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5 MG
€156.00
25 MG
€619.00

About This Item

Empirical Formula (Hill Notation):
C22H28FNO3
CAS Number:
139290-65-6
Molecular Weight:
373.46
MDL number:
MFCD00909060
UNSPSC Code:
12352200
PubChem Substance ID:
329817971
NACRES:
NA.77

€156.00

Please contact Customer Service for Availability
Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

off-white to light brown

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

COc1cccc([C@H](O)C2CCN(CC2)CCc3ccc(F)cc3)c1OC

InChI

1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3/t21-/m1/s1

InChI key

HXTGXYRHXAGCFP-OAQYLSRUSA-N

Gene Information

human ... HTR2A(3356)

General description

M100907 blocks the serotonin 2A (5-HT2A) receptors and imposes antidepressant-like effects.[1] It may be used for treating dopaminergic anomalies.[2]

Biochem/physiol Actions

M100907 is a selective 5-HT2A Antagonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000231275
0000231275
0000163486
0000163487
0000163486

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Peter S Talbot et al.
NeuroImage, 59(1), 271-285 (2011-07-26)
Scanning properties and analytic methodology of the 5-HT2A receptor-selective positron emission tomography (PET) tracer 11C-MDL100907 have been partially characterised in previous reports. We present an extended characterisation in healthy human subjects. 64 11C-MDL100907 PET scans with metabolite-corrected arterial input function
Paul J Fletcher et al.
Neuropharmacology, 61(3), 468-477 (2011-03-16)
Previous work has shown that 5-HT(2C) receptor agonists and 5-HT(2A) receptor antagonists reduce impulsive action, as well as the locomotor stimulant effect of psychomotor stimulants. Since psychomotor stimulants also increase impulsive action we examined the effects of the 5-HT(2C) receptor
Angela J Rylands et al.
Biological psychiatry, 72(12), 1004-1011 (2012-07-28)
Impulsive aggression (IA) in adults is associated with brain serotonin (5-HT) system abnormalities and is more common following childhood adversity. Within aggressive behavior, IA and callous unemotional (CU) traits are core components of differentiable factors with opposing 5-HT abnormalities. We
Lara A Pockros et al.
Psychopharmacology, 213(2-3), 307-320 (2010-11-17)
The action of serotonin (5-HT) at the 5-HT(2A) receptor subtype is thought to be involved in cocaine-seeking behavior that is motivated by exposure to drug-associated cues and drug priming. 5-HT(2A) receptors are densely clustered in the ventromedial prefrontal cortex (vmPFC)
Mona E Hervig et al.
Psychology & neuroscience, 13(3), 438-458 (2021-02-23)
Adapting behavior to a dynamic environment requires both steadiness when the environment is stable and behavioral flexibility in response to changes. Much evidence suggests that cognitive flexibility, which can be operationalized in reversal learning tasks, is mediated by cortico-striatal circuitries
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