K2768
KHS1, active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
GCKR, MAP4K5, MAPKKKK5
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About This Item
UNSPSC Code:
12352204
NACRES:
NA.32
recombinant
expressed in baculovirus infected Sf9 cells
Quality Level
product line
PRECISIO® Kinase
Assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
76-99 nmol/min·mg
mol wt
~135 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... MAP4K5(11183)
Biochem/physiol Actions
KHS1 (kinase homologous to SPS1/STE20) is a component of MAP (mitogen activated protein) kinase signaling pathway and is responsible for activation of JUNK (c-Jun N-terminal kinase). Mutation in the promoter region of KHS1 is linked with lower risk of type 2 diabetes. It is also referred to as MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5)
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Maura Epifanía Matus-Ortega et al.
Biochimica et biophysica acta, 1769(3), 194-203 (2007-03-06)
PNPase is a phosphate-dependent exonuclease of Escherichia coli required for growth in the cold. In this work we explored the effect of specific mutations in its two RNA binding domains KH and S1 on RNA binding, enzymatic activities, autoregulation and
C S Shi et al.
Journal of immunology (Baltimore, Md. : 1950), 163(6), 3279-3285 (1999-09-08)
TNF-induced activation of stress activated protein kinases (SAPKs, Jun NH2-terminal kinases) requires TNF receptor associated factor 2 (TRAF2). TRAF2 is a potent activator of a 95-kDa serine/threonine kinase termed germinal center kinase related (GCKR, also referred to as KHS1), which
Yanyun Gu et al.
Journal of human genetics, 51(7), 605-610 (2006-05-16)
MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5), an early component of MAP kinase signal cascades was shown to activate Jun kinase in mammalian cells. The association between SNPs of MAP4K5 and type 2 diabetes (T2DM) was investigated due to
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