This product is soluble in 0.05 M acetic acid (10 mg/ml) as well as water (1 mg/ml).
G1895
Gly-Pro-Arg-Pro
≥95% (HPLC)
Synonym(s):
GPRP, Glycyl-Prolyl-Arginyl-Proline amide
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5 MG
€254.00
25 MG
€894.00
€254.00
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5 MG
€254.00
25 MG
€894.00
About This Item
Empirical Formula (Hill Notation):
C18H31N7O5
CAS Number:
Molecular Weight:
425.48
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
€254.00
Please contact Customer Service for Availability
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Quality Level
Assay
≥95% (HPLC)
storage temp.
−20°C
SMILES string
NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2CCC[C@H]2C(O)=O
InChI
1S/C18H31N7O5/c19-10-14(26)24-8-2-5-12(24)15(27)23-11(4-1-7-22-18(20)21)16(28)25-9-3-6-13(25)17(29)30/h11-13H,1-10,19H2,(H,23,27)(H,29,30)(H4,20,21,22)/t11-,12-,13-/m0/s1
InChI key
WXPZDDCNKXMOMC-AVGNSLFASA-N
Gene Information
human ... FN1(2335)
mouse ... FN1(14268)
rat ... FN1(25661)
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Amino Acid Sequence
Gly-Pro-Arg-Pro
General description
Gly-Pro-Arg-Pro is a peptide that mimics the N-terminal Gly-Pro-Arg region in the α chain of fibrin protein.[1]
Application
Gly-Pro-Arg-Pro (GPRP) has been used for the formation of crystal composed of GPRP and the 30kDa C-terminal fragment from the γ chain of fibrinogen (rFbgγC30), cloned and expressed in Pichia pastoris.[1]
Biochem/physiol Actions
Gly-Pro-Arg-Pro (GPRP) is capable of increasing free thrombin.[2] Thus it can be utilized to make thrombin-degranulated platelets, which helps in studying platelet reactions.[3]
Gly-Pro-Arg-Pro peptide suppresses the early steps of fibrin polymerization. The amide derivative of this peptide prevents the degradation of fibrinogen and fragment D by plasmin, even in the presence of EGTA (ethylene glycol-bis (β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid).[4]
Inhibits fibrin polymerization.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Ramesh Ramapanicker et al.
Bioconjugate chemistry, 24(1), 17-25 (2012-11-16)
The synthetic tetrapeptide GPRP based on the amino-terminal GPR sequence of the fibrin α-chain binds the D-dimer protein with a dissociation constant K(D) of 25 μM. The D-dimer protein, a well-known biomarker for thrombosis, contains two cross-linked D fragments from
The use of the synthetic peptide, Gly-Pro-Arg-Pro, in the preparation of thrombin-degranulated rabbit platelets
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Hi. I received fly-pro-arg-pro. G1895 5 mg. CAS-No:67869-629. You don’t mention where to dilute it and how much to dilute the powder in. Can you please help?
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