D103
(±)-2,3-Dichloro-α-methylbenzylamine hydrochloride
solid
Synonym(s):
DCMB, LY-78335
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About This Item
Empirical Formula (Hill Notation):
C8H9Cl2N · HCl
CAS Number:
Molecular Weight:
226.53
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
form
solid
color
white
solubility
H2O: soluble (Solutions may be stored for 1-2 days at 4 °C.)
ethanol: soluble (Solutions may be stored for 1-2 days at 4 °C.)
SMILES string
Cl[H].CC(N)c1cccc(Cl)c1Cl
Gene Information
human ... PNMT(5409)
Biochem/physiol Actions
PNMT inhibitor.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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S P Kalra
Neuroendocrinology, 40(2), 139-144 (1985-02-01)
Adult female rats were implanted with permanent cannulae in the third ventricle of the brain and allowed to recover regular 4-day estrous cycles. They received intrajugular cannulae on the morning of proestrus and later between 12.00-13.00 h catecholamines - norepinephrine
I N Mefford et al.
Alcoholism, clinical and experimental research, 14(1), 53-57 (1990-02-01)
The probable involvement of brain epinephrine in the expression of the acute sedative and intoxicating effects of ethanol and pentobarbital is demonstrated. Two selective inhibitors of phenylethanolamine N-methyltransferase (PNMT), LY134046 and LY78335, proved to be potent and long-lasting antagonists of
L C Terry et al.
The Journal of clinical investigation, 69(1), 104-112 (1982-01-01)
Catecholamines are postulated to regulate growth hormone (GH) secretion by their influence on the release of two hypothalamic substances, somatostatin, which inhibits GH release, and GH-releasing factor, as yet unidentified. Extensive pharmacologic studies in man and animals indicate a stimulatory
N Y Liang et al.
Research communications in chemical pathology and pharmacology, 37(3), 445-452 (1982-09-01)
Inhibitors of phenylethanolamine N-methyltransferase (PNMT) were found to reduce hypothalamic and brainstem epinephrine (Epi) content, as well as the body temperature of male Sprague-Dawley rats. In the drug-treated animals, the time course for reduction of body temperature was better correlated
B A Adler et al.
Endocrinology, 113(4), 1431-1438 (1983-10-01)
Results from previous investigations have suggested an important role for central epinephrine (EPI) systems in mediating the stimulatory effects of ovarian hormones on LH release in ovariectomized female rats. The purpose of these experiments was 1) to test whether selective
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