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Carboxylesterase 2 human

Name: Carboxylesterase 2 human
Brand: SIGMA
Price: 595 EUR

recombinant, expressed in mouse NSO cells, ≥95% (SDS-PAGE)

Synonym(s):

CES2, CES2A1

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Size/SKU	Availability	Price
10 μg	Please contact Customer Service for Availability	€595.00

About This Item

UNSPSC Code:

12352204

NACRES:

NA.54

EC Number:

3.1.1.1 (BRENDA, IUBMB)

Specific activity:

≥1.0 EU/μg, 30,000 pmol/min-μg protein

Assay:

≥95% (SDS-PAGE)

Recombinant:

expressed in mouse NSO cells

Concentration:

0.4-0.6 mg/mL

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Properties

recombinant

expressed in mouse NSO cells

Quality Segment

200

assay

≥95% (SDS-PAGE)

form

solution

specific activity

≥1.0 EU/μg, 30,000 pmol/min-μg protein

mol wt

predicted mol wt ~60 kDa

concentration

0.4-0.6 mg/mL

impurities

≤1.0 EU/μg endotoxin

NCBI accession no.

NM_003869, NP_003860

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CES2(8824)

Description

Biochem/physiol Actions

Human carboxylesterase 2 (hCE-2) recognizes a substrate with a large alcohol group and small acyl group. Its substrate specificity may be restricted by a capability of acyl-hCE-2 conjugate formation due to the presence of conformational interference in the active site pocket. Carboxylesterases catalyze the biotransformation of several ester-containing drugs and prodrugs such as angiotensin-converting enzyme inhibitor (temocarpil, cilazapril), anti-tumor drugs (capecitabin) and narcotics.[1]

Member of a serine esterase family that hydrolyze ester and amide bonds. Carboxylesterase 2 is an endoplasmic reticulum-bound hydrolase that plays a critical role in xenobiotic detoxification and activation for ester-containing therapeutics. Carboxylesterase 2 is also involved in the detoxification of drugs such as heroin and cocaine. This enzyme is thought to play a role in lipid metabolism.

Physical form

Supplied as a solution containing sodium chloride, sodium acetate, and 20% glycerol.

Other Notes

One unit will cause the hydrolysis of 1 picomole of p-nitrophenylacetate per minute at pH 7.5 at 25 deg C.

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1 of 1

This Item	SAB1406734	E0412	SAB1405606
Sigma-Aldrich C4749 Carboxylesterase 2 human	Sigma-Aldrich SAB1406734 Anti-CES2 antibody produced in mouse	Sigma-Aldrich E0412 Carboxylesterase 2 human	Sigma-Aldrich SAB1405606 Anti-CES1 antibody produced in mouse
Gene Information human ... CES2(8824)	Gene Information human ... CES2(8824)	Gene Information -	Gene Information human ... CES1(1066)
assay ≥95% (SDS-PAGE)	assay -	assay -	assay -
specific activity ≥1.0 EU/μg, 30,000 pmol/min-μg protein	specific activity -	specific activity ≥500 units/mg protein	specific activity -
concentration 0.4-0.6 mg/mL	concentration -	concentration -	concentration -
form solution	form buffered aqueous solution	form liquid	form buffered aqueous solution
recombinant expressed in mouse NSO cells	recombinant -	recombinant expressed in baculovirus infected BTI insect cells	recombinant -

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pictograms

GHS08

signalword

Danger

hcodes

H334

pcodes

P261 - P284 - P501

Hazard Classifications

Resp. Sens. 1

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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