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CNQX disodium salt hydrate

Name: CNQX disodium salt hydrate
Brand: SIGMA

≥98% (HPLC), solid, AMPA/kainate receptor antagonist.

Synonym(s):

6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt hydrate

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About This Item

Empirical Formula (Hill Notation):

C₉H₂N₄Na₂O₄ · xH₂O

CAS Number:

115066-14-3

Molecular Weight:

276.12 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

24277972

NACRES:

NA.77

MDL number:

MFCD09953908

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

protect from light

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Product Name

CNQX disodium salt hydrate, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

orange to red

solubility

H₂O: >2 mg/mL (warmed)

SMILES string

O.[Na+].[Na+].[O-]c1nc2cc(C#N)c(cc2nc1[O-])[N+]([O-])=O

InChI

1S/C9H4N4O4.2Na.H2O/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5;;;/h1-2H,(H,11,14)(H,12,15);;;1H2/q;2*+1;/p-2

InChI key

LCDWHGXMFAZHEO-UHFFFAOYSA-L

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Bioactive Small Molecules

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This Item	C127	N183	M3568
Sigma-Aldrich C239 CNQX disodium salt hydrate	Sigma-Aldrich C127 CNQX	Sigma-Aldrich N183 NBQX disodium salt hydrate	Sigma-Aldrich M3568 MSX-3 hydrate
form solid	form solid	form lyophilized powder	form solid
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage condition protect from light	storage condition protect from light	storage condition desiccated	storage condition protect from light
solubility H₂O: >2 mg/mL (warmed)	solubility DMSO: >10 mg/mL, H₂O: insoluble	solubility H₂O: >10 mg/mL	solubility H₂O: soluble >5 mg/mL at 60 °C
color orange to red	color yellow	color , brown to dark red-brown	color pale yellow

Application

CNQX disodium salt hydrate has been used as:

as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)
as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)
as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)

Biochem/physiol Actions

Potent, competitive AMPA/kainate receptor antagonist.

CNQX(6-cyano-7-nitroquinoxaline-2,3-dioneis) is a potent, competitive AMPA/kainate receptor antagonist. It is a quinoxaline derivative and also an antagonist for non-N-methyl-d-aspartate (non-NMDA) glutamate receptor. CNQX mediates depolarization thalamic reticular nucleus via α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs). It displays micromolar affinity towards AMPA/kainate receptor.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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CNQX Blocks Kainate-induced Corneal Irritation

Ibitokun, Bernadette O and Miller, Kenneth E

investigate opthalmology and visual science, 53(14), 1855-1855 (2012)

Medicinal chemistry of competitive kainate receptor antagonists

Larsen, Ann M and Bunch, Lennart

ACS Chemical Neuroscience, 2(2), 60-74 (2010)

Binge-like consumption of a palatable food accelerates habitual control of behavior and is dependent on activation of the dorsolateral striatum.

Teri M Furlong et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(14), 5012-5022 (2014-04-04)

Access to highly palatable and calorically dense foods contributes to increasing rates of obesity worldwide. Some have made the controversial argument that consumption of such foods can lead to "food addiction," yet little is known about how long-term access to

Layer III neurons control synchronized waves in the immature cerebral cortex.

Shigehiro Namiki et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(3), 987-1001 (2013-01-18)

Correlated spiking activity prevails in immature cortical networks and is believed to contribute to neuronal circuit maturation; however, its spatiotemporal organization is not fully understood. Using wide-field calcium imaging from acute whole-brain slices of rat pups on postnatal days 1-6

Calmodulin kinase IV-dependent CREB activation is required for neuroprotection via NMDA receptor-PSD95 disruption.

Karen F S Bell et al.

Journal of neurochemistry, 126(2), 274-287 (2013-02-01)

NMDA-type glutamate receptors mediate both trophic and excitotoxic signalling in CNS neurons. We have previously shown that blocking NMDAR- post-synaptic density-95 (PSD95) interactions provides significant protection from excitotoxicity and in vivo ischaemia; however, the mechanism of neuroprotection is unclear. Here

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Global Trade Item Number

SKU	GTIN
C239-5MG	04061833475768
C239-100MG	04061832089713
C239-25MG	04061833475751

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