C1860
Anti-Clathrin Heavy Chain antibody, Mouse monoclonal
clone TD.1, purified from hybridoma cell culture
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About This Item
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biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
TD.1, monoclonal
form
buffered aqueous solution
mol wt
antigen 180-192 kDa
species reactivity
rat, human, bovine, mouse
concentration
~2 mg/mL
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 2-4 μg/mL using whole extract of cultured rat adrenal pheochromocytoma PC-12 cells.
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CLTC(1213)
mouse ... Cltc(67300)
rat ... Cltc(54241)
General description
Clathrin, a three legged structure refer as triskelion is the main component of polygonal network and forms the coat of coated vesicles and coated pits. Clathrin-coated vesicles accounts for receptor mediated endocytosis at the plasma membrane and also play a crucial role in hormone secretion and mechanism of action. Monoclonal Anti-Clathrin Heavy Chain antibody can be used to study the mechanism of clathrin mediated membrane trafficking during hormonal stimulation and protein phosphorylation. Mouse monoclonal anti-clathrin heavy chain antibodies are react specifically with clathrin heavy chain CHC17 but do not cross react with muscle isoform CHC22.
Immunogen
globular N-terminal domain of bovine clathrin heavy chain.
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Monoclonal Anti-Clathrin Heavy Chain antibody can be used in immunoblotting. It can also be used in western blotting to characterize clathrin heavy chain levels
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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P Narducci et al.
European journal of histochemistry : EJH, 54(1), e6-e6 (2010-04-01)
Bone is continuously repaired and remodelled through well-coordinated activity of osteoblasts that form new bone and osteoclasts, which resorb it. Osteoblasts synthesize and secrete two key molecules that are important for osteoclast differentiation, namely the ligand for the receptor of
I S Näthke et al.
Cell, 68(5), 899-910 (1992-03-06)
The triskelion shape of the clathrin molecule enables it to form the polyhedral protein network that covers clathrin-coated pits and vesicles. Domains within the clathrin heavy chain that are responsible for maintaining triskelion shape and function were identified and localized.
David Rhainds et al.
Journal of cell science, 117(Pt 15), 3095-3105 (2004-07-01)
The scavenger receptor class B, type I (SR-BI) mediates cholesteryl esters (CE) selective uptake from low density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. In a number of tissues expressing caveolin, SR-BI is localized in caveolae. We show using detergent-free
Chunjiang Yu et al.
Molecular neurodegeneration, 5, 19-19 (2010-05-19)
One pathological hallmark of Alzheimer's disease (AD) is amyloid plaques, composed primarily of amyloid-beta peptide (Abeta). Over-production or diminished clearance of the 42 amino acid form of Abeta (Abeta42) in the brain leads to accumulation of soluble Abeta and plaque
Nicholas Rinkenberger et al.
Virology, 533, 59-67 (2019-05-22)
Zika virus (ZIKV) is an emerging pathogen with global health and economic impacts. ZIKV circulates as two major lineages, Asian or African. The Asian lineage has recently been associated with significant disease in humans. Numerous studies have revealed differences between
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