B0261
Bufalin
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Synonym(s):
3β,14-Dihydroxy-5β,20(22)-bufadienolide, 5β,20(22)-Bufadienolide-3β,14-diol
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Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
10 mg | Please contact Customer Service for Availability | €377.00 |
About This Item
assay
≥97% (HPLC)
Quality Segment
form
solid
solubility
DMF: soluble, DMSO: soluble, ethanol: soluble
storage temp.
2-8°C
SMILES string
O[C@]([C@@](CC[C@@]1([H])[C@@]2(CC[C@H](O)C1)C)([H])[C@]2([H])CC3)(CC[C@@H]4C(C=C5)=COC5=O)[C@]34C
InChI
1S/C24H34O4/c1-22-10-7-17(25)13-16(22)4-5-20-19(22)8-11-23(2)18(9-12-24(20,23)27)15-3-6-21(26)28-14-15/h3,6,14,16-20,25,27H,4-5,7-13H2,1-2H3/t16-,17+,18-,19+,20-,22+,23-,24+/m1/s1
InChI key
QEEBRPGZBVVINN-BMPKRDENSA-N
General description
Application
- to test its effect on invasion and activation of nuclear factor kappa- B (NF-κB) cells and tumor necrosis factor-α (TNF-α) stimulated rheumatoid arthritis fibroblast-like synoviocytes (RAFLSs)
- as a nuclear receptor coactivator 3 (NCOA3) inhibitor in chondrocytes
- to test its anti-metastasis effect in lung cancer cells (NCI-H460) resistant to gefitinib
Biochem/physiol Actions
1 of 1
This Item | |||
|---|---|---|---|
| description - | description phyproof® Reference Substance | description A cardiotonic steroid isolated from toads of Bufo species that potently inhibits ouabain-sensitive Na+,K+-ATPase activity (IC50 = 1.4 nM). | description ≥98% (HPLC) |
| form solid | form - | form solid | form powder |
| assay ≥97% (HPLC) | assay ≥95.0% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 200 | Quality Level - | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C |
| solubility DMF: soluble, DMSO: soluble, ethanol: soluble | solubility - | solubility DMSO: 25 mg/mL, warm ethanol: 25 mg/mL | solubility DMSO: 2 mg/mL, clear |
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Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 2 Oral
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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