Synthetic peptide directed towards the N terminal region of human SMARCD3
Biochem/physiol Actions
SMARCD3 belongs to SWI/SNF family of proteins that exhibit helicase and ATPase activities. It epigenetically activates Wnt5a signaling in human mammary epithelial cells and controls the epithelial-mesenchymal transition.
Sequence
Synthetic peptide located within the following region: KRVDIQEALKRPMKQKRKLRLYISNTFNPAKPDAEDSDGSIASWELRVEG
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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Molecular and cellular biology, 33(15), 3011-3025 (2013-05-30)
We previously identified a gene signature predicted to regulate the epithelial-mesenchymal transition (EMT) in both epithelial tissue stem cells and breast cancer cells. A phenotypic RNA interference (RNAi) screen identified the genes within this 140-gene signature that promoted the conversion
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