AV35098
Anti-KCNN4 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Anti-IK1, Anti-IKCA1, Anti-KCA4, Anti-KCa3.1, Anti-SK4, Anti-Small conductance calcium-activated channel, subfamily N, member 4, Anti-hIKCa1, Anti-hKCa4
Sign Into View Organizational & Contract Pricing
All Photos(2)
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
mol wt
48 kDa
species reactivity
human
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... KCNN4(3783)
General description
Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, KCNN4, is a component of a potassium channel activated by calcium. It is critically involved in calcium ion transport and cell homeostasis.
Immunogen
Synthetic peptide directed towards the C terminal region of human KCNN4
Application
Anti-KCNN4 antibody produced in rabbit has been used in:
- western blot analysis
- immunofluorescence
- staining
- immunohistochemistry
Biochem/physiol Actions
KCNN4 (potassium calcium-activated channel subfamily N member 4) is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. KCNN4 may be part of the predominant calcium-activated potassium channel in T-lymphocytes. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
Sequence
Synthetic peptide located within the following region: DLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
The potassium channel KCa3. 1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke
Chen YJ, et al.
Journal of Cerebral Blood Flow and Metabolism, 36(12), 2146-2161 (2016)
Bradykinin-induced chemotaxis of human gliomas requires the activation of KCa3. 1 and ClC-3
Cuddapah VA, et al.
The Journal of Neuroscience, 33(4), 1427-1440 (2013)
D Strøbæk et al.
British journal of pharmacology, 168(2), 432-444 (2012-08-16)
The K(Ca) 3.1 channel is a potential target for therapy of immune disease. We identified a compound from a new chemical class of K(Ca) 3.1 inhibitors and assessed in vitro and in vivo inhibition of immune responses. We characterized the
Javier Lozano-Gerona et al.
PloS one, 15(3), e0222619-e0222619 (2020-03-10)
Ion channels have recently attracted attention as potential mediators of skin disease. Here, we explored the consequences of genetically encoded induction of the cell volume-regulating Ca2+-activated KCa3.1 channel (Kcnn4) for murine epidermal homeostasis. Doxycycline-treated mice harboring the KCa3.1+-transgene under the
A Novel Gene, hKCa4, Encodes the Calcium-activated Potassium Channel in Human T Lymphocytes
Logsdon NJ, et al.
The Journal of Biological Chemistry, 272(52), 32723-32726 (1997)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service